Capsid and Tail

a weekly phage periodical

Have an idea for a story, news to share, or wanting to write an opinion piece? Get in touch at [email protected] or tweet @phagedirectory

Latest Issue
Issue 37: Phage therapy in the human gut
July 18, 2019

Phage therapy in the human gut

This week, Sabrina Green, a graduate student at Baylor College of Medicine, tells us how gut pathogens like ExPEC could be treated with phages, describes the challenges, and highlights her own research on the topic.
Stay On Top of Phage

Capsid & Tail is a weekly periodical that follows the ins and outs of phage research, jobs, and phage therapy.

Issue 36: A phage enthusiast’s highlights from ASM Microbe 2019
July 11, 2019

A phage enthusiast’s highlights from ASM Microbe 2019

This week, Siân Owen, a postdoctoral fellow studying prophage biology at Harvard University, gives us the scoop on the phage side of this year’s ASM Microbe conference.
Issue 35: Regulating phage therapy
July 4, 2019

Regulating phage therapy: Let’s build a foundation for our future

This week, Dan Evans, a research technician in the Van Tyne lab at the University of Pittsburgh, takes us through the regulatory challenges keeping phage therapy out of the mainstream, highlights ways to overcome these hurdles, and suggests tangible action items for the phage community that could make a difference.
Issue 34: Involving high school students in phage research
June 27, 2019

Involving high school students in phage research

This week, we’re showcasing how Karen Adler, an MSc student in Dr. Ronen Hazan's lab in Jerusalem, involves high school students in her phage research. She describes the phage work their lab is doing with the students, highlights a few success stories, and tells us how she inspires her students.
Issue 33: Phage therapy applications in aquaculture
June 20, 2019

Phage Therapy Applications in Aquaculture

Bacterial diseases cause significant losses in the global fish farming (aquaculture) industry, and phages are being explored as a solution.
Issue 32: The Declaration of Helsinki and Phage Therapy
June 14, 2019

The Declaration of Helsinki and Phage Therapy

When compassionate phage therapy case reports are described in published works, the Declaration of Helsinki often gets mentioned. But where did this declaration come from, why is it referenced so often, and how does it apply to phage therapy?
Issue 31: Phage Requests at the Queen Astrid Military Hospital
June 7, 2019

How the Queen Astrid Military Hospital processes phage requests

The Queen Astrid Military Hospital in Brussels has treated patients with phages since 2007, but lately, they've had a lot more phage therapy requests. This week, we're highlighting a recent report describing who's doing the requesting, what kinds of infections they're seeing, and how they handle all these requests.
Issue 30: Phage Therapy in India
May 30, 2019

Improving access to phage therapy in India

We interviewed Pranav Johri, a former phage therapy patient who founded Vitalis Phage Therapy to help others access phage therapy, especially in his home country of India.
Issue 29: OSU Viromics Workshop
May 23, 2019

Exploring viral ecology tools at the OSU Viromics Workshop

UC Denver postdoc Dr. Anushila Chatterjee attended this year's Ohio State University Viromics Workshop. Here's her report on what was covered!
Issue 28: Phage banks
May 17, 2019

Phage banks around the world

Where can you buy phages, and where can you deposit yours? This week, we take a tour of phage banks around the world.
Issue 27: First case of engineered phage therapy
May 9, 2019

First case of engineered phage therapy

This week, we highlight a new paper documenting the first use of engineered phages in human therapy, published yesterday by Rebekah Dedrick, Carlos Guerrero-Bustamante, and colleagues in Nature Medicine.
Issue 26: Book Review: Perfect Predator
May 2, 2019

Book Review: The Perfect Predator

What love, community, and phages can do: this week, we bring you a review of Steffanie Strathdee and Tom Patterson's phage therapy memoir, The Perfect Predator.
Issue 25: Phages as diagnostic tools
April 25, 2019

Phages as diagnostic tools

Beyond therapeutics, phage-based diagnostics show the versatility of phages in biotech. This week, guest writer Cathy Nguyen takes us through three examples of phage-based diagnostics.
Issue 24: Compassionate phage therapy
April 18, 2019

Compassionate phage therapy

Where is the world at with compassionate phage therapy? This week, Dr. Shawna McCallin highlights a new review (co-authored with us at Phage Directory and with Dr. Ben Chan at Yale) of phage case reports published to date.
Issue 23: Phage therapy and pregnancy
March 28, 2019

Phages to treat our most vulnerable patients

Should phage therapy be considered for pregnant women? This week, Dr. Lucy Furfaro introduces the field of perinatal phage research.
Issue 22: Israel's First Phage Therapy Case
March 21, 2019

Collaboration leads to phage therapy success

The first case of phage therapy in Israel shows how patients can benefit from collaborations between academia, medicine, military and biotech.
Issue 21: Using zebrafish to model phage therapy
March 14, 2019

Using zebrafish to model phage therapy

This week, we highlight a useful new animal model for the phage therapy community.
Issue 20: Commercializing phage therapy
March 8, 2019

How do we commercialize phage therapy? A full recap of Phage Futures 2019

We attended Phage Futures 2019 at the end of January, and now present our full recap of the event.
Issue 19: What's it like to help with phage crowdsourcing?
February 28, 2019

What's it like to help with phage crowdsourcing?

To understand what it's like to take part in phage crowdsourcing, we interviewed five labs who've contributed phages on behalf of a patient.
Issue 18: Studying phage-host coevolution
February 22, 2019

Studying phage-host coevolution in the lab

How is phage-host coevolution studied in the lab, and what can it tell us?
Issue 17: Incentives for phage drug development
February 15, 2019

Incentives for phage drug development

A look into government incentives for antimicrobial development, and how they apply to phage therapeutic development.
Issue 16: Patents vs. trade secrets
February 8, 2019

Alternatives to patenting phages: trade secrecy

In past issues, we covered what it means to patent something & whether patenting works for phages. In this issue, we dive into an alternative to patenting: trade secrecy.
Issue 15: Impressions of Phage Futures 2019
February 1, 2019

Impressions of Phage Futures 2019

This week, we attended Phage Futures Congress 2019, which we found to be a huge success!
Issue 14: Patenting phages, part II
January 24, 2019

Patenting phages, part II: What makes something patentable?

Simply having a patent on something doesn’t actually protect your invention. That patent has to actually hold up in court. How is this determined, and what kind of chance do phages stand?
Issue 13: Breaking down phage patentability
January 17, 2019

Breaking down phage patentability

You may have heard through the grapevine that “phages can’t be patented”, but several phage patents exist, and biotech and pharma are investing in phage-based therapeutics. What’s the deal?
Issue 12: Where in the world (and how) can I get phage therapy?
January 10, 2019

Where in the world (and how) can I get phage therapy?

People are starting to ask questions about phage therapy. We need your help to put together an FAQ. Do they qualify? How can they get it, and where do they get it?
Issue 11: Uncultivated viral genomes
January 3, 2019

New reporting standards for uncultivated viral genomes

Have you submitted genome sequences for phages that haven’t been cultured yet? Here’s what you should report if and when you do.
Issue 10: Capsids in the Classroom
December 21, 2018

Capsids in the classroom (and a challenge for 2019)

This week, we’re sharing insights from our experience talking to middle school kids about phages, phage therapy, and Phage Directory.
Issue Nine: Q&A with BiomX
December 14, 2018

Tweaking the microbiome with phages: Q&A with BiomX CBO Assaf Oron

This week, we bring you a Q&A with BiomX CBO Assaf Oron.
Issue Eight: Belgian Phage Therapy
December 7, 2018

Belgium’s new brand of phage therapy

This week, we explore Belgium's unique new way of treating patients with phages...
Issue Seven: Crowdsourcing Special
November 30, 2018

Special issue: An update on our current phage crowdsourcing campaign

To provide a window into what happens during a phage hunt, we're devoting this issue to showing some of what's happened over the last three weeks. We've put together an infographic to help illustrate how labs across the globe have come together in support of this cause.
Issue Six: Thanksgiving
November 22, 2018

Happy (American) Thanksgiving!

We’re incredibly humbled by all the wonderful feedback and for your help in spreading the word about Capsid & Tail and Phage Directory. Thank you!!
Issue Five: Reflecting
November 15, 2018

Reflecting on our first year

For this week’s issue, we’d like to reflect on our first year as Phage Directory. We’re one year old this week!
Issue Four: Crowdsourcing
November 8, 2018

Phage crowdsourcing

This is the second post in a series on how patients are being treated with phages outside of traditional clinical trials.
Issue Three: eIND
November 2, 2018

"The eIND route”: How do people currently get phage therapy in the US?

This is the first of a series of posts about how patients are being treated with phages outside of traditional clinical trials.
Issue Two: Clinical Trials
October 26, 2018

Clinical trials: Are phages “there yet”?

You may have heard that phages "still haven’t made it through clinical trials.” What does this mean, and is anyone making any progress on this?
Issue One
October 18, 2018

Phage therapy returns to the US

Welcome to the first issue of Capsid & Tail, a mini-periodical of links, topics, and commentary that covers the ins and outs of the phage world.

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