C&T Round Up for May 2022!

Issue 178 | June 3, 2022
5 min read

This week, we highlight the feature articles we published in May! Learn about the latest Mycobacterium phage treatment, how we might make our spot tests less subjective, how to get involved in DeSci, and what a phage biologist thought of this year’s ECCMID.

What’s New

Adaptive Phage Therapeutics announced that the first patient has been dosed in its DFO Adaptive Novel Care Evaluation (DANCE™) trial, a Phase 1/2 clinical study to evaluate the safety and efficacy of APT’s precision phage therapy in patients with Diabetic Foot Osteomyelitis.

Biotech newsClinical TrialPhage Therapy

Preprint: Gram-positive bacteria evade phage predation through endolysin-mediated L-form conversion. Read author Martin Loessner’s Twitter thread on this report!

L-formsPhage-host interactionsPreprint

Opinion: Diversity in the soil virosphere: to infinity and beyond? Read author Simon Roux’s Twitter thread on this report!

OpinionSoil viruses

Paper: Phage-mimicking nanoagents for rapid depolymerase specificity screening against multidrug resistant bacteria.

DepolymerasesNanotechResearch paper

News article: Rediscovering phages: ‘We finally have the tools to harness them’.

NewsPhage Therapy

Latest Jobs

Laboratory Technician
Laboratory specialist to join the Van Tyne Lab in the Division of Infectious Diseases at University of Pittsburgh, which studies how bacteria evolve resistance to antibiotics and host immune defenses during human infection. Responsibilities include bacterial culture, antimicrobial susceptibility, phage susceptibility, and other phenotype testing, PCR, molecular cloning, and next-generation library preparation and sequencing.
BioinformaticsIntracellular phagesPhD projectPhage and food
Funded PhD position in the labs of John Kenny @ the Teagasc Food Research Centre and Jenn Mahony @ UCC. The project involves detecting intracellular phages through sequencing, coupled to traditional phage screening approaches. The candidate will validate these technologies and improve our understanding of how phages use their hosts as a Trojan horse to interfere with food fermentations.
Laboratory TechnicianStructural Biology
Laboratory Researcher III in Kaelber Lab at Rutgers University to understand the molecular and structural basis of viral infection using cutting-edge structural biology methods
MicrobiologyResearch Fellow
Research Fellow in Microbiology at Monash University
BioinformaticsPhage TherapyPost Doc
Postdoctoral Fellowship at CSIRO in Phage Therapy Bioinformatics
Phage biologyResearch Fellow
Research Fellow in Phage Biology/Microbiology at University of Warwick (part of Monash Warwick Alliance Combatting AMR)
SEA-PHAGESTeaching Assistant
Teaching Assistant in SEA-PHAGE Phage Discovery at McGill University, Canada
BiologyLecturer
Lecturer in Biology at Gonzaga University
Lab Manager
Microbiology Manager at Phico Therapeutics, UK

Community Board

Anyone can post a message to the phage community — and it could be anything from collaboration requests, post-doc searches, sequencing help — just ask!

iVoM Season 2, hosted by ISVM, VoM 2022 and Phage Directory concluded recently with its 7th event.

The recordings of all the events are now posted on the members page!

The events spanned all aspects of viruses of microbes, and each feature 3 x 10 min talks followed by a combined Q&A and topic discussion.

If you’d like to see these videos but didn’t attend the series, you can still register here.

Given that VoM 2022 is approaching next month, after a 2-year hiatus due to COVID, it’s a great time to catch up on everything viruses-of-microbe!

Thanks so much to all who joined and to our speakers and chairs!

iVoMISVMViruses of Microbes

We warmly invite you to attend you to attend our 12th annual Oxford bacteriophage conference – the longest running phage conferences series in Europe – which will be held on 05-06 September 2022.

We are committed to holding this conference as a ‘virtual-in-person’ hybrid event at our traditional venue of St Hilda’s College, Oxford, UK (COVID-19 situation permitting).

Get involved in shaping the conference agenda, which will include most aspects of bacteriophage research and application in medicine, food and biotechnology. We welcome proposals for speakers and topics.

We invite emerging researchers, including final-year doctoral students and early-/mid-career postdoctoral researchers/junior group leaders to play an active role in putting together ECR symposia on topics of their interest in the field, and to apply to present.

Please email [email protected] with any questions.

ConferencePhage biology

Hi everyone, I have isolated a few phages - 2 are Jumbo phage. I have sequnced (350 kbp) these phages. I need help in sequence analysis and can collaboratively publish it. Email: [email protected]

BioinformaticsSeeking collaborator

I was wondering if there was an unpublished case of a phage therapy done which I could write a case report about. If so please contact me at [email protected]

Case studySeeking collaborator

C&T Round Up for May 2022!

Profile Image
Phage microbiologist and co-founder of Phage Directory
Co-founderPostdoctoral Researcher
Skills

Phage characterization, Phage-host interactions, Phage Therapy, Molecular Biology

I’m a co-founder of Phage Directory and have a Ph.D in Microbiology and Biotechnology from the University of Alberta (I studied Campylobacter phage biology). For Phage Directory, I oversee community building, phage sourcing, communications, science, and our awesome team of volunteers.

As of Feb 2022, I’ve recently joined Jon Iredell’s group in Sydney, Australia as a postdoctoral research scientist for the Phage Australia project. I’m diving back into the lab to help get Phage Australia’s country-wide phage therapy system up and running here, working to streamline workflows for phage sourcing, biobanking and collection of phage/bacteria/patient matching and monitoring data, and integrating it all with Phage Directory’s phage exchange, phage alerts and phage atlas systems.

In this month’s Capsid & Tail Monthly Round Up issue, we’re highlighting the two feature articles we published in May. Be sure to check them out if you missed them, and let us know if you have thoughts, comments or questions! Reach us anytime by email or Slack!

C&T Throwback!

There’s lots of great phage stuff in the C&T archive! Check out this article on ɛ²-phages: naturally bred high-tech phages which are superior to wild types in critical properties by David Sáez and Lorenzo Corsini!


Thanks so much to Atif Khan and Stephanie Lynch for collecting and summarizing links to share for this week!

Capsid & Tail

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Leona M. and Harry B. Helmsley Charitable Trust

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