Jobs

Monash University in Melbourne, Australia is hiring faculty in Genomics/Genetics and Ecology/Environmental Sciences.

Jessica Blair (Univ. of Birmingham) and Martha Clokie (Univ. of Leicester) are recruiting a PhD student to work on using phages to turn off bacterial efflux pumps.

University of Toronto is hiring for a phage-related faculty position: “We are interested in candidates who are applying bioinformatics, chemical biology and structural biology to important questions in the biology and biochemistry of bacteriophage life cycles.”

Outstanding candidates are invited to apply for independent group leader positions in any of the 12 scientific departments on its campus in Paris, France.

Institut Pasteur is a non-profit private foundation dedicated to fundamental, interdisciplinary research and to the translation of knowledge for applications in medicine and public health (https://research.pasteur.fr/en/departments/). Located in central Paris, it offers an outstanding and unparalleled research environment with state-of-the-art research laboratories, and 20 technology platforms, including a core facility with four cutting-edge cryo-electron microscopes allowing single particle analysis and cellular tomography.

Successful junior candidates will be appointed with a permanent position, and as head of a group of 6 people. These groups will be created for a period of 5 years and may thereafter compete for a full research group.

Recently, it has been demonstrated that inherited symbionts may protect their hosts from certain pathogens. Such protective phenotypes are potentially beneficial in terms of host fitness, and thus could aid symbiont establishment. This prediction is supported through ecological modeling, but has rarely been tested in natural settings.

Solitary bees and Wolbachia bacteria will be used as model host/symbiont system. The candidate will investigate natural populations of bees and measure symbiont and viral titres in different species collected in and around Oxfordshire. These data will be used to determine if symbiont infection status predicts viral loads. Further, the candidate will characterize symbiont genomes through Nanopore and Illumina sequencing and use pool-Seq to determine which genomic features of the symbionts correlate negatively with viral presence. Further, novel viruses potentially interacting with symbionts will be described through viral metagenomics of solitary bee samples.

Breast milk from mothers who deliver preterm is nutritionally distinct from term breast milk and contains a microbiome that has higher numbers of Coagulase negative Staphylococcus. Little is known about the ‘phageome’ of preterm breast milk. Recent work from our group has identified that the presence of Staphylococcus is common in the preterm gut microbiome and that LOS may be gut mediated. We hypothesise that higher phage titre in breast milk will reduce Staphylococcal load at the mucosal surface and protect preterm infants from gut mediated LOS. To test this hypothesis we will seed enteroid models with phages isolated from preterm breast milk and examine the infection profile of Staphylococci isolated from preterm stool and blood culture. Identifying how phages infect bacteria and modulate microbiome development using a biologically relevant model will allow us to develop novel therapies to protect the immature gut of preterm infants.

It is widely recognised that the gut microbiota plays an important role in human health and has become one of the most dynamic, complex and exciting areas of research in both food and pharmaceutical arenas. The microbiota is not only a target for treatment and prevention of disease, it is a repository for functional food ingredients and even new drugs and is a source of novel biomarkers of disease risk.

The advertised position is within APC’s Gut Phageomics Laboratory, consisting of over 20 researchers investigating the role of the gut bacteriophages in health and disease. The Post-Doctoral Researcher will work within this lab as part of the APC’s ‘Gut Phageomics Spoke’ which is collaborating with a major multi-national pharmaceutical company to explore the role of bacteriophages in shaping the human gut microbiome.

This project is aimed at evaluating the use of bacteriophage to treat Staphyloccocus aureus colonization and/or disease in order to better combat multi-antibiotic-resistant bacterial pathogens. A major goal of this project is to establish and utilize animal models to investigate the potential of phage treatment against S. aureus to decolonize the upper respiratory tract and/or to treat S. aureus infections. However, other aspects will delve into aspects of the genetics of bacteriophage that are relevant to their deployment in these contexts. These include genetic mechanisms of bacterial resistance to phage and mechanisms of phage adaptation to infect different or new hosts.

Under the guidance of a mentor, the participant will be involved with the following project activities: animal models of infection and phage treatment, isolation of mutant bacterial and bacteriophage strains, genetic engineering of bacterial and bacteriophage strains, isolation of bacteriophage from natural sources, next generation DNA sequence analysis.

The PHE Culture Collections is a Biological Resource Centre that provides a service maintaining and supplying strains of cultured cells and microorganisms for public health research. It is structured as a fully integrated service, underpinning science with significant scientific, manufacturing and business activities and operates from laboratories across the PHE.

The successful post holder will be a member of the laboratory operations team and duties will including: the propagation and quality control of bacteriophage and the cultivation, freeze drying and banking of bacterial strains within the National Collection of Type Cultures (NCTC); replenishment and upkeep of inventory and test records; and also maintaining the electronic database.

The successful candidate should hold a Microbiology degree or equivalent qualification. Experience in working in a microbiology laboratory is essential and practical experience in working with bacteriophages will be a significant advantage.

Bacteriophages often carry auxiliary metabolic genes that are used by the phage to augment host metabolism to maximise phage replication. These genes often overcome metabolic bottlenecks encountered by their bacterial hosts and point towards the most important limiting factor in an ecosystem. Amazingly they have not been examined in the rainforest and such genes may be of key importance to understand ecosystem function from a bottom up perspective.

This project will use both culture-based and culture-independent methods to study bacteriophages from Belum rainforest and from the Amazon that are associated with hallmark plant species. The project will specifically investigate the viral communities in soil surrounding different plant species.

Intralytix is currently seeking an experienced Research Scientist to work at our laboratories. The successful candidate will participate in various research projects focused on the development of bacteriophage-based products, with a focus on human health applications. This is a hands-on bench-based position and requires proficiency in microbiology and molecular biology techniques. The salary and position level will be commensurate with experience and qualifications. The benefits package includes health insurance, company paid life insurance and long-term disability insurance, paid parking, and 401(K) with matching company contribution.

MilliporeSigma is seeking a Scientist for our Virology and Microbiological Sciences Team. This is a hands-on laboratory position to help new product development and optimize performance of current products for MilliporeSigma customers.

This position will be responsible for the following: perform virus titer assays using infectivity, qPCR and plaque enumeration; prepare and characterize stocks of bacteriophage and mammalian viruses; execute filtration and chromatography studies to characterize virus retention characteristics of membranes and resins; execute virus inactivation studies; contribute to method development and validation; preparation of test methods and reports.

A postdoctoral research position is available in the laboratory of Eric Nelson MD PhD at the Emerging Pathogens Institute, University of Florida. The overall goal of our laboratory is to develop better methods to improve the care, diagnosis and management of patients during large-scale diarrheal disease outbreaks. Our model system is cholera and our primary collaborative field sites are in Bangladesh and Haiti. In the field, our research focuses on identifying and characterizing key selective pressures that drive disease severity and transmission. At the University of Florida, we test hypotheses derived from the field studies in animal models of infection and transmission.

The current available project lies at the physiologic interface between host and pathogen. Specifically, the first phase of research involves characterizing the microbiota of human diarrheal disease samples and identifying antimicrobial factors important to pathogenesis and transmission (e.g. antibiotics by LC/MS and bacteriophage).

PhagoMed is looking for a high calibre business developer to join our team in Vienna, Austria.

Role description:

• Identify new business opportunities, incl. analyzing new indications to pursue, grant opportunities, co-development programs and in-licensing, out-licensing options that are aligned with our portfolio strategy
• Conduct detailed research on indications for which PhagoMed already has development programs, incl. socioeconomic impact of the indication, market access, sales & marketing aspects
• Support the Managing Directors throughout the fundraising process incl. through by writing pitch decks, identifying potential investors and planning and executing the investment rounds
  […]

A Postdoctoral Research Associate position in microbiology is available immediately in the lab of Dr. Patrick Secor as part of an interactive multidisciplinary research team focused on bacteriophage biology at the University of Montana. The Postdoctoral Research Associate will work under the supervision of Dr. Secor to complete the exciting research on a novel antibacterial vaccine targeting bacteriophages.

We are recruiting for a Research Assistant- Phage Genomics to be an active member of Prof Chris Creevey’s Group supporting a research project emphasing bacteriophages and the rumen microbiome. The successful candidate will undertake research under supervision into the potential for bacteriophages to modulate the rumen microbiome.

This project integrates synthetic biology, in vitro and in vivo experiments and mathematical modelling to predict and test the effectiveness and consequences of CRISPR-Cas9-mediated removal of antibiotic resistance from clinical pathogens in a realistic gut environment. The Van Houte lab has (1) a large collection of clinical isolates of carbapenem-resistant E. coli and K. pneumoniae, and vancomycin-resistant E. faecium, which will be subjected to CRISPR-Cas9 to remove drug resistance, and (2) a collection of conjugative elements and bacteriophages that will be tested as delivery vehicle for CRISPR-Cas9. We will assess how factors such as antibiotics levels, microbial community composition, delivery vehicle host range and transmission mode will influence the efficiency of CRISPR-Cas9 to remove resistance from clinical isolates.

Seeking a research technician to:

• Assist with our directed evolution project with the purpose of improving the efficiency and safety of gene insertion tools.
• Assist with conducting a wide variety of molecular biology techniques, some of which include: Phage assisted continuous evolution (PACE); complex plasmid design and construction; lentivirus preparation and transduction; work with bacteriophage; Fluorescence-activated cell sorting (FACS); and tissue culture including embryonic stem cell culture, southern and western blotting, polymerase chain reaction (PCR) experiments and optimization, T7 assays, and novel assays designed to test deoxyribonucleic acid (DNA) binding and targeted insertion of piggyBac and other integrating proteins.

We are looking for a research assistant to plan and perform laboratory work at and beyond the state-of-the-art in the areas of cloning, cell culture, recombinant expression, and protein purification of soluble and membrane proteins and complexes. Techniques used will include Gibson assembly cloning, sequence- and ligation-independent cloning and other cloning methods, CRISPR/Cas9-based bacterial genome modification, protein purification (including affinity purification, ion exchange, size exclusion chromatography), gradient-based ultracentrifugation, reconstitution of proteins into nanodiscs and proteolipsomes, bacteriophage production.

Janssen R&D LLC. is currently seeking to recruit a Microbiology Leader, Scientific Director, for a research and development team within the Infectious Diseases and Vaccines Therapeutic Area to be located in Spring House, PA.

The Microbiology Leader, Scientific Director, will be responsible for overseeing the day-to-day operations of a small a multi-disciplinary team focused on the discovery and development of novel antibacterial agents, such as bacteriophage, targeting key bacterial pathogens for infectious diseases associated with high unmet medical needs.

Bayside Solutions is seeking a Scientist II to be part of our client’s team in the East Bay Area. This is an opportunity to work with the largest privately held pharmaceutical corporation in the world and ranks among the world’s 20 leading pharmaceutical corporations.

The individual will work in a small team of individuals in the design and early development. Experience working with bacteriophage, viruses, or Smarticles technology is preferred.

This position will focus on developing improved reverse genetic tools for viruses using synthetic genomics and CRISPR-based tools to manipulate virus genomes and recover viable virus leading towards a more complete understanding of viruses that lack robust genetic tools, such as agricultural pathogens and bacteriophages, and to develop modified viruses for therapeutic applications. The position requires a candidate with proficiency in microbiology and molecular biology.

The Departments of Molecular Biology and Biochemistry (MBB) and of Ecology and Evolutionary Biology (EEB) at the University of California, Irvine, invite applications for two tenure-track assistant professorships in microbiome research.

1. Host-microbiome interactions. Our goal is to hire a researcher who is not focused on a particular disease, but rather investigates how to disentangle host-microbiome interactions broadly across diseases or animal hosts. Potential research areas for the position include (but are not limited to) investigating how the microbiome mediates host responses to pathogen infection, chemical challenge or injury, altering host metabolism or influencing host development or homeostasis.

2. Evolution of microbiomes. Microbial evolution within a community context is key to understanding how microbiomes respond to disturbance. Within humans or other hosts, a disturbance might be a change in diet, disease progression, or administration of a treatment or probiotic. Potential research areas for the position include (but are not limited to) the evolution of antibiotic resistance in a community context, the evolution of microbiomes in response to global change, the evolution of drug metabolism, host-microbiome coevolution, or the comparative evolution of microbiomes across hosts.

The researchers would join an actively growing and collaborative group of campus faculty studying the microbiomes of hosts and the environment, organized and facilitated by the UCI Microbiome Initiative.

The Department of Plant and Environmental Science invites applications for a tenure-track assistant professor position within the field of bacteriophage biology with start 1 May 2020, or as soon as possible thereafter.

The impact of microbes on the health of eukaryotes is increasingly recognized in both human-, animal- and plant-related research. Surrounding- and regulating the distribution of the microbes are the bacteriophages, often outnumbering the bacteria 10:1. The bacteriophages thereby act as modulators of bacterial communities and may have great future biotechnological potential as both biocontrol agents and as a source of new biotechnological enzymes.

The position is advertised in connection to a newly established Environmental Microbial Genomics (EMG) group headed by Professor Lars Hestbjerg Hansen to address this major knowledge gap within phage biology.

The Adriaenssens group at the Quadram Institute Bioscience (QIB), in collaboration with the School of Computing Sciences at the University of East Anglia, is looking to recruit a PhD student on a fully funded project. In this project, we will use machine learning approaches for the detection of RNA virus genomes in microbiome data and investigate their role in the human gut. The student will join the group of Dr Evelien Adriaenssens at QIB, specialised in gut viruses and viromics, with Dr Gavin Cawley, a specialist in machine learning, as second supervisor.

We are recruiting a student at the Quadram Institute Bioscience (QIB) on the role phages play in the establishment of the gut microbiota, particularly focused on beneficial bifidobacteria. The student will join the team of Dr Evelien Adriaenssens, an expert in phage biology, and that of Dr Lindsay Hall, an expert in the infant gut microbiome. In this project, the student will use established methods to discover new bacteriophages against bifidobacteria and investigate their effects on natural bacterial communities in the infant gut through model systems and next-generation sequencing.

The Department of Biology at Gonzaga University invites applications for a Biology Lab Specialist to prepare laboratory facilities for the teaching of multi-section laboratory courses, to assist with the implementation of lab curricula, to teach lab sections, and to supervise teaching assistants and student workers. The labs are the first semester component of the HHMI SEA-PHAGES program (Science Education Alliance – Phage Hunters Advancing Genomics and Evolutionary Science), which is a classroom-based undergraduate research experience. Students use microbiology and molecular techniques to discover, purify, and characterize bacteriophages from soil.

We are looking for a highly motivated and dynamic researcher for a 2-years post doc position in Bacteriophage biology and application starting on January 1st 2020 or as soon as possible hereafter. The post doc will have a major role in testing the safety and efficacy of bacteriophages targeting porcine enterotoxigenic E. coli as a part of the AVANT project funded by the European Commission. The aim of this project is to collect pre-clinical data by testing the safety and efficacy of a phage-based product targeting porcine ETEC. You will work in the PhageBio group in Copenhagen headed by Professor Lone Brøndsted and alongside post doc Michela Gambino. For more information about our research see here. Please note that only online applications can be considered: apply here.

Are you interested in soil phages and inter-kingdom interactions? Apply to the DOE Office of Science Graduate Student Research Program and come collaborate with us at the Pacific Northwest National Lab (PNNL).

Award Benefits

• A monthly stipend of up to $3,000/month for general living expenses
• Reimbursement of inbound/outbound traveling expenses to/from the host DOE laboratory/facility of up to $2,000

Eligibility

• U.S. Citizen or Lawful Permanent Resident
• Qualified graduate program & Ph.D. Candidacy
• Graduate research aligned with an SCGSR priority research area
• Establishment of a collaborating DOE laboratory scientist at the time of application

Applications must be submitted via the official website. Please contact Michelle Davison michelle.davison@pnnl.gov to discuss potential collaborations!

The Bondy-Denomy lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new and ongoing projects. Our lab focuses on CRISPR-Cas immune systems and their natural functions in bacteria. We are also interested in developing new tools stemming from both Type I and II CRISPR-Cas systems, both for inhibitor proteins and new applications for these systems in microbes (see Bondy-Denomy et al., Nature 2015, Rauch et al., Cell 2017, Marino et al. Science 2018, Jiang et al. Mol Cell 2018).

The candidate will be expected to contribute to this tool development and CRISPR biology work in the lab, by conducting microbiology and molecular biology techniques, including bacterial and bacteriophage manipulation, cloning, protein purification, and biochemical assays. An exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and participate in procurement of funds, where appropriate. Additionally, the specialist will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a positive lab citizen.

We are hiring a post doc to work on gut phages in IBD! If you are interested in metagenomics and phage biology and fancy living three years in beautiful Paris, please get in touch.

This is a funded 3-year position open from June 2020. The successful candidate will work at the interface between the fundamental and clinical research on characterization of virome dynamics associated with faecal, mucosal and blood samples of IBD patients. Contact: luisa.de_sordi@sorbonne-universite.fr.

The Department of Biochemistry and Molecular Biology at Michigan State University seeks outstanding applicants for a tenure-track position at the Assistant/Associate level with expertise in cryo-electron microscopy (Cryo-EM) and the ability to develop a vigorous, externally funded research program that will complement existing strengths in the areas of structural, membrane protein, computational, biomedical, microbial, and plant biochemistry. Michigan State University is building and committed to expand a state-of-the-art Cryo-EM facility. We are currently operational with a Talos Arctica outfitted with a phase plate and Falcon 3 camera to support this research area.

The Cluster of Excellence Balance of the Microverse at the Friedrich Schiller University combines expertises in life, optical, material and computational sciences to elucidate the role of microbiomes in different habitats in order to identify overarching regulatory principles that can be harnessed to address societal needs in healthcare and environmental stewardship.

We encourage applications from researchers with a broad experience in viral ecology, including aquatic ecosystems or other habitats.

We are looking for an individual experienced in theoretical ecology with focus on microbiology, systems biology theory development, bioinformatics and/or modelling.

Leonyte Biosystems is a fast-paced biotechnology start-up in Berlin, developing new in vitro diagnostics for detecting pathogens in food. We are looking to grow our team with a Microbiologist with strong experience in molecular biology to assist in the development of bacterial detection and identification tests for the food industry. The successful applicant will have experience in S2 bacterial culturing techniques, working with bacteriophage, general molecular biology techniques (e.g. real-time PCR, ELISA, cloning) as well as microscopy techniques (e.g. Gram-staining, DAPI staining, use of confocal fluorescence microscope). Previous experience within the food industry and in vitro diagnostics is a plus.

Antimicrobial Resistance (AMR) Interdisciplinary Research Group of Singapore-MIT Alliance for Research and Technology is seeking a full-time Laboratory Assistant or Laboratory Technologist to join a dynamic team working on antibacterial drug resistance mechanisms and bacteriophages.

We are seeking a postdoc to join an NIH supported project on phage therapy to investigate the role of the immune system during the treatment of pneumonia initiated by the opportunistic pathogen Pseudomonas aeruginosa. This project will be carried out in collaboration with the team of Prof. Joshua Weitz (Georgia Tech, USA) – a group specializing in theory and models of viral dynamics. We are looking for a motivated candidate with a degree-qualified (MD, PhD, DVD) in microbiology, immunology, molecular biology, infectious disease, or closely related fields.

The postdoc will lead efforts to develop analytical and computational models of virus-microbe interactions with an emphasis on viral control of microbial community dynamics. Requirements include: (1) PhD in quantitative biosciences, physics, ecology, evolutionary biology, applied mathematics, or related area; (2) Strong quantitative & computational skills; (3) Excellent communication skills; (4) Interest and experience in collaborative research and model-data integration, including collaborative opportunities in the USA and France. Position to start in Fall 2019/Spring 2020; start date negotiable, includes competitive salary, benefits, and travel budget.

Applications are invited for a Postdoctoral Research Associate in BREX phage-resistance systems.

BREX methylates the host at specific recognition sequences, but the mechanism of BREX phage protection is not yet understood. This research programme contains three interconnected objectives: (1) Define the essential components and interactions within BREX loci using an E. coli model; (2) Define the biochemical activity and structure of BREX components and/or complexes; (3) Define how bacteriophages become BREX-resistant. These aims will be achieved using a range of techniques including microbiology, molecular biology, biochemistry, structural biology (X-ray crystallography, cryo-EM) and genomics. The project will be supported by two PhD studentships. The post is full time and fixed term for 36 months.

Tim Blower can be contacted for informal enquiries at timothy.blower@durham.ac.uk

The Bio-Behavioral Research Operation of Leidos is currently looking for a Research Assistant to support biological research in support of the Biological Defense Research Directorate (BDRD) at the Naval Medical Research Center (NMRC) in Frederick, MD. The BDRD within NMRC facilitates biological research for the rapid detection of infectious diseases of global importance and the enhancement of global disease surveillance for early pathogen detection and response.

We are looking for an enthusiastic, dedicated postdoctoral fellow with a strong interest in multi-species molecular microbiology to contribute to our ongoing research on colonization resistance in zebrafish. The project aims at characterizing key determinants of microbiota-based resistance to infection using bacterial genetics, fish immunology, genomics, quantitative analysis of bacterial dynamics and imaging. We expect this project to provide insights into the molecular events underlying pathogen exclusion in a controlled multispecies in vivo context.

[Note from Phage Directory: Not a phage-specific position, but we think phage people could bring a lot to this project!]

The Aylward lab at Virginia Tech is seeking a post-doctoral researcher interested in the evolution and genomics of DNA viruses. The researcher will have the opportunity to work in several areas of ongoing research in the laboratory, including the isolation and genomic analysis of bacteriophage and other DNA viruses, cultivation of diverse hosts, analysis of evolutionary relationships and genomic repertoires of different viral groups groups, and the development of bioinformatic methods for genomic and evolutionary analyses.

The advertised position is within APC’s Gut Phageomics Laboratory, consisting of over 20 researchers investigating the role of the gut bacteriophages in health and disease. The Post-Doctoral Researcher will work within this lab as part of the APC’s ‘Gut Phageomics Spoke’ which is collaborating with a major multi-national pharmaceutical company to explore the role of bacteriophages in shaping the human gut microbiome.

A&P Inphatec, LLC is commercializing the first product to treat Pierce’s Disease in grapevines. Our unique solution utilizes bacteriophages to target and kill the bacteria at the source of the problem – giving wine growers an organic and sustainable solution to a rising threat in California.

A&P Inphatec, LLC is seeking a highly motivated and detail-oriented applicant to join our research and development team as a full-time Research Technician. This individual will be responsible for processing field trial samples, microbiological media preparation, and maintenance of cell stocks.

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

The institute of Virology is seeking a highly motivated postdoctoral bioinformatician for the newly funded ERC project, for omics analysis, with a particular emphasis on bacteriophage communities.

Armata is seeking a Research Associate I/II to work with the R&D team. The candidate will support the overall program goals and strategy of the group, which include significant laboratory activities such as phage engineering and characterization, protein expression and preclinical evaluation of phage therapy efficacy in relevant animal models.

The Director will provide an important leadership role in Microbiology by overseeing the day to day operation of the ContraFect Microbiology Laboratory and the performance of clinical microbiology development studies in the field of protein-based therapeutics to treat serious bacterial infections. The laboratory is a major site for the conduct of clinical microbiologic testing of our lead compound, CF-301, in support of marketing authorization applications (NDA/BLA, MAA), approval and eventual clinical use if approved.

The Talbert Research Group in the Department of Food Science & Human Nutrition at Iowa State University seeks a Postdoctoral Research Associate to join a multidisciplinary group focused on protein chemistry and enzyme technology. The successful candidate will leverage their expertise in genetic engineering and recombinant protein production to support federally funded projects aimed at the design and modification of bacteriophage for biotechnology applications.

The Biomedical Technician shall work with/in Naval Medical Research Center-Frederick Biological Defense Research Directorate’s Genomics Department. The Genomics Department has a mission to apply bioinformatics and cutting edge, high-throughput technologies such as genotypic and phenotypic expression profiling, biomarker characterization, bacteriophage science, etc. to the study of infectious diseases, biodefense, and enhanced global disease surveillance for early pathogen detection and response.

A full-time Professional Research Assistant (PRA) position is available, starting immediately, to work in the laboratory of Dr. Breck Duerkop in the Department of Immunology and Microbiology, University of Colorado School of Medicine. The Duerkop lab studies Gram-positive pathogenic enterococci, including Enterococcus faecalis and E. faecium, and the viruses that infect these bacteria known as bacteriophages. Dr. Duerkop’s group seeks to understand how bacteriophage-enterococcal interactions contribute to the pathogenesis of colonization and disease.

We are looking for passionate and driven scientists with expertise in synthetic biology to join our international and highly motivated team in Paris working on next-generation tools for editing the microbiome (engineered phages, CRISPR systems, etc.). The ideal candidate can copy, paste and edit genetic code on a plasmid or a genome as easily as using Word.

We are looking for passionate and driven scientists with significant experience in drafting patent applications to join our international and highly motivated team in Paris working on engineered phages and CRISPR phages. The ideal candidate has experience in microbiology, phage biology and molecular biology.

We are looking for passionate and driven scientists with expertise in phage biology to join our international and highly motivated team in Paris working on engineered phages and CRISPR phages. The ideal candidate loves phages, robots, discovery, and managing large amounts of data, and will become a key member of our Discovery and Automation team!

We are looking for passionate and driven scientists with expertise in testing phage treatments in animals to join our international and highly motivated team in Paris working on engineered phages and CRISPR phages. The ideal candidate has strong skills in animal handling and knowledge in animal models for phage treatments.

The Emerson Lab at the University of California, Davis is seeking a Postdoctoral Researcher to lead a project in soil and/or rhizosphere viral ecology using omic approaches, particularly metagenomics and/or metatranscriptomics. We are looking for a postdoc with a strong bioinformatics background to dive into this exciting new field. There is a fair amount of flexibility with regard to project choice, including the potential to publish quickly by taking a leading role in the continuation of existing projects (e.g., spatiotemporal dynamics of soil viral and microbial communities under different management practices in a tomato/corn rotation), and/or the potential to develop a new project. Apply by Aug. 9, 2019 for full consideration.

Required Special Knowledge, Skills, and Abilities:

• Hands-on research experience related to phage biology.
• Familiar with operating and maintaining common laboratory and/or technical equipment.
• Familiar with maintaining common research supplies.
• Ability to conduct microbiology and molecular biology research independently, including analyzing data and writing reports.
• Ability to supervise undergraduate students. Ability to multi task and work cooperatively with others.
• Ability to multi-task and work cooperatively with others.

Job Responsibilities
40%: Maintain common laboratory and/or technical equipment, and train new users. Maintain common research supplies. Maintain laboratory safety records and protocols. Organize and update laboratory research protocols and research material stocks.

55%: Work on sponsored researched projects independently. Analyze data and write scientific reports independently. Supervise undergraduate students and help train graduate students working on related projects.

5%: Other Duties as required

BiomX is a leading Israeli biotech company developing microbiome-based novel therapeutics. We are looking for a highly-motivated M.Sc.-level research assistant to join our Microbiology team. By joining this team, you will be part of novel research in the microbiome field and the development of phage therapies.

Micreos Food Safety develops natural phage products against dangerous bacteria in the food chain and is viewed as product leader in this field. During your internship, you will assist our researchers in the laboratory on current Research and Development projects. The practical work will mainly involve microbiological techniques in relation to the isolation, characterization, and lab-scale production of bacteriophages. The internship is for a time period of 5 to 6 months (longer is possible).

Postdoctoral positions are immediately available in the laboratories of Dr. Elizabeth Villa and Dr. Joe Pogliano in the Department of Biology at the University of California San Diego. We are seeking highly-motivated, energetic and passionate individuals to join our collaborative team to study Pseudomonas phage that replicate using a nucleus-like structure. The project focuses on using a combination of cryo-electron microscopy, fluorescence microscopy, CRISPR/Cas gene editing tools, proteomics, and RNA seq to identify and study the structure and function of every essential protein encoded by these unique phage. The “phage nucleus” is a new field of biology that is incredibly rich with a high potential for making novel discoveries. The applicant should have a Ph.D., M.D., or equivalent title in biology and have a demonstrated record of productivity.

[If you enjoyed the paper on phage “treadmilling” we highlighted above, here’s a chance to work with the group who made that discovery!]

CARB-X, a Boston University Global Partnership, has an exciting opportunity for a talented individual to join our core team at Boston University in the role of Director of Research & Development. CARB-X is a new organization located at the BU School of Law, focused on accelerating the pre-clinical development of drugs, vaccines and diagnostics to address antibiotic resistance. The Director of R&D is a new senior role on the leadership team of CARB- X. The Director of R&D will take responsibility for the planning, review, awarding and monitoring of novel R&D projects addressing the antimicrobial resistance issue on a global basis.

PhagePro is looking for a Principal Scientist to carry forth our research for our phage-based cholera intervention as we scale-up our studies in preparation for clinical trials. We are a flat and dynamic organization, and the Principal Scientist is crucial to our success in the field. The position is for one year, and it is located at PhagePro’s lab space at the Tufts Launchpad in Boston, MA.

Intralytix is currently seeking a Research Scientist to work at our laboratories in downtown Baltimore, Maryland. The successful candidate will participate in various research projects focused on the development of bacteriophage based products for food safety and / or human health applications.

Do you want to be part of pioneering a high-profile antibiotics alternative and lead the research into breakthrough phage applications in areas of high medical need – together with a highly talented team and a network of leading physicians? Then apply for PhagoMed’s current vacancy as Senior Scientist - Phages.

Role description:

• Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data);
• Further establish and validate potency model for phages against bacteria in biofilm models and planktonic growth;
• Analyze the effect of phages on bacteria, including MIC, time-kill curves and other relevant parameters for antimicrobials, resistance formation, in planktonic growth and on biofilms
• Further develop the PhagoMed phage breeding protocols to enhance selected properties of our target phages, e.g. lytic activity in biofilm and pharmacokinetics;
• Evaluate immune response to phages;
  […]

Do you want to be part of developing a high-profile antibiotics alternative and help drive the research into new phage-based pharmaceuticals – together with an experienced and motivated team and a network of leading physicians? Then apply for PhagoMed’s current vacancy as Junior Researcher.

Role description:

• Execute series of experiments to support the developmental program, all following established protocols, including:
• Production and purification of bacteriophages for scientific research
• Activity testing of phages against bacterial strains (BSL-2 strains like S. aureus, E. coli, other)
• Selective breeding of phages
• Host range analyses
• Biofilm assays
• Isolation of bacteriophages from human and environmental samples
• Characterization of bacteriophages (adsorption rate, latency period, burst size)
  […]

Do you want to be part of pioneering a high-profile antibiotics alternative and lead the research into breakthrough phage applications in areas of high medical need – together with a highly talented team and a network of leading physicians? Then apply for PhagoMed’s current vacancy as Senior Scientist - Phages.

Role description:

• Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data);
• Further establish and validate potency model for phages against bacteria in biofilm models and planktonic growth;
• Analyze the effect of phages on bacteria, including MIC, time-kill curves and other relevant parameters for antimicrobials, resistance formation, in planktonic growth and on biofilms
• Further develop the PhagoMed phage breeding protocols to enhance selected properties of our target phages, e.g. lytic activity in biofilm and pharmacokinetics;
• Evaluate immune response to phages;
  […]

Do you want to be part of developing a high-profile antibiotics alternative and help drive the research into new phage-based pharmaceuticals – together with an experienced and motivated team and a network of leading physicians? Then apply for PhagoMed’s current vacancy as Junior Researcher.

Role description:

• Execute series of experiments to support the developmental program, all following established protocols, including:
• Production and purification of bacteriophages for scientific research
• Activity testing of phages against bacterial strains (BSL-2 strains like S. aureus, E. coli, other)
• Selective breeding of phages
• Host range analyses
• Biofilm assays
• Isolation of bacteriophages from human and environmental samples
• Characterization of bacteriophages (adsorption rate, latency period, burst size)
  […]

The Technician I, under general supervision, assists in planning research on support laboratory methods and techniques, carrying out procedures, and recording results for a series of closely-controlled experiments.

Preferred Education And Experience:

• B.S. in Biochemistry or Microbiology
• Research experience in microbiology laboratories.
• Independent research experience in bacteriophage projects.

Preferred Knowledge, Skills And Abilities

• Knowledge of standard microbiology and molecular biology laboratory skills.
• Skills working with bacteriophage, including isolation, culturing and characterization. Skills in bioinformatics analysis of bacteriophage genomes.

PhagoMed is also looking for a high-calibre molecular biologist to join their lysin team as Senior Scientist.

Role:

• Establish research processes according to the latest microbiological technology developments (e.g. robotics and genomic data);
• Further establish and validate potency model for endolysins against bacteria in (mucosal) biofilm and planktonic growth;
• Assembly of bacterial panels for species of interest, including in silico analysis of geno- and serotypes, to ensure required genetical and geographical breadth
  (…)

PhagoMed, an Austrian biotech company focused on the development of human therapeutic applications of phages and phage-derived proteins, is looking for a Group Leader for their Lysins group. This role will involve leading the research into breakthrough lysin applications in areas of high medical need – together with a highly talented team and a network of leading physicians.

Role:

• Take the full responsibility to advance the pharmaceutical endolysin development program against the milestones of the development plan
• Coordinate the development workstreams between the lab work in Vienna, the work at our academic and commercial research partners and any relevant external parties (e.g. Regulatory Consultants)
  (…)

Isolation of novel bacteriophages, including characterization by electron microscopy and comparative genomics

The project aims to discover new phage in samples we have collected from diverse environments across the world, to characterize new features in phage morphology by cryo-electron microscopy, and to understand evolutionary linkages through comparative genomics.

More info and applications through: trevor.lithgow@monash.edu

ICON Government and Public Health Solutions specializes in preclinical through phase IV support of clinical research and clinical trial services for biologics, drugs, and devices. The candidate would perform research on bacteriophages and microbial pathogens of military relevance (e.g. Staphylococcus aureus, Shigella, Pseudomonas, Klebsiella, etc.), including in-depth bacteriophage characterization and animal modeling.

The Leptihn Group offers a Postdoctoral Fellowship: The project involves viruses of microbes (bacteriophages) with aspects on both function and structure of phage proteins, as well as phage therapy. Experience in imaging and protein biochemistry or microbiology are desired.

A Research Fellow is required within the School of Life Sciences to support a new project in collaboration with partners in China entitled ‘Novel biocontrol to combat Clostridium perfringens in poultry flocks’. Ideally you will have a strong background in microbiology/molecular biology and some knowledge of bacteriophage technology.

We are looking for a highly motivated and dynamic researcher for a 2 year position, to commence August 1, 2019. The position is related to role of bacteriophages in the transfer of antibiotic resistance genes in Staphylococcus and the extent to which such transfer takes place in biofilms. We have a multinational research environment with strong national and international collaborators.

The successful candidate will be involved in laboratory activities mainly on the detection, isolation, and characterization of bacteriophages from environmental samples, as well as identification of Shiga Toxin-producing E. coli (STEC).

We have an exciting new postdoc training and research opportunity recently made possible via the acquisition of a VA Merit Award to discover and develop therapeutic phages to treat E. coli infections in a murine model of CAUTI (catheter associated urinary tract infection). This is a unique opportunity to engage a growing phage therapy presence and group at Baylor (Department of Molecular Virology and Microbiology) and the Texas Medical Center in Houston, Texas.

The Barr Lab research group is studying bacteriophages within the context of their bacterial and mammalian hosts. We are offering an excellent opportunity to engage in an exciting post-doc position that combines microbiology, cell biology, genetics, evolution and microscopy within both in vitro and in vivo model systems. A number of research project are available within the lab for the right applicant, including, but not limited to:

• Interaction of temperate phages within the human gut microbiome and characterising the tripartite symbioses they form with bacterial and animal hosts.
• Phage therapy with a focus on identifying mechanism of phage infectivity and translation of results into the clinic.
  Applicants are encouraged to read through the Barr lab website, including research directions and expectations, for further information on how to apply.

A research opportunity is available in the Division of Bacterial, Parasitic and Allergenic Products (DBPAP) within the Food and Drug Administration (FDA) in Silver Spring, Maryland. This project is aimed at evaluating the use of bacteriophage to treat Staphyloccocus aureus colonization and/or disease in order to better combat multi-antibiotic-resistant bacterial pathogens.

The Wang Laboratory of Molecular Food Safety invites applications for a postdoctoral research fellow position. The successful candidate will execute research on the characterization of the microbial pathogen Rhizobium radiobacter (Agrobacterium tumefaciens) and its interaction with bacteriophages.

We are seeking highly qualified investigators who use definitive approaches to understand the nature of the microbiome and its impact on host physiology and disease susceptibility. Candidates are sought with expertise in areas related to microbiology, including, but not limited to, microbe-microbe interactions, microbehost interactions, microbial ecology, microbial enzymology and biochemistry, bacteriophage therapy, and the role of microbiota in cancer biology and response to immunotherapy.

We are looking for a postdoc with strong quantitative skills as well as expertise in bioinformatics and computational genomics. The general aim of the project is to explore the diversity and specificity of interactions between bacteriophages and opportunistic bacterial pathogens in the family of Enterobacteriaceae, with primary emphasis on Klebsiella pneumoniae.

The Howard Hughes Medical Institute has an opening for a Research Technician to join the laboratory of Dr. Michael Laub in the Biology Department at the Massachusetts Institute of Technology. Principal research interests of the Laub laboratory include toxin-antitoxin systems, phage biology, and chromosome organization.

The Novick lab at the NYU School of Medicine is seeking a research technician to perform laboratory experiments such as bacterial cultures, strain isolation, genetic tests, experiments with mice; manage lab - order supplies, maintain inventory, maintain equipment. Lab project: Conversion of highly mobile phage related staphylococcal pathogenicity islands into antibacterial agents. The project is described in the following article.

Studying the infection mechanisms of archaeal viruses can provide insight into the evolutionary history of viruses and help to understand adaptation to extreme environments. In the framework of a recently awarded Emmy Noether grant, we offer an excellent opportunity to engage into an exciting PhD project that combines microbiology, genetics, microscopy and biochemical tools in the context of a dynamic and enthusiastic work environment, with state-of-the-art equipment and various chances for national and international scientific collaborations.

Studying the infection mechanisms of archaeal viruses can provide insight into the evolutionary history of viruses and help to understand adaptation to extreme environments. In the framework of a recently awarded Emmy Noether grant, we offer an excellent opportunity to engage into an exciting post-doc project that combines microbiology, genetics, microscopy and biochemical tools in the context of a dynamic and enthusiastic work environment, with state-of-the-art equipment and various chances for national and international scientific collaborations.

CARB-X, a Boston University Global Partnership, has an exciting opportunity for a talented individual to join our core team at Boston University in the role of Director of Research & Development. CARB-X is a new organization located at the BU School of Law, focused on accelerating the pre-clinical development of drugs, vaccines and diagnostics to address antibiotic resistance. The Director of R&D will take responsibility for the planning, review, awarding and monitoring of novel R&D projects addressing the antimicrobial resistance issue on a global basis. *Note: CARB-X is one of the current funding possibilities for phage research and development, so we are posting this here!

The Novick lab at the NYU School of Medicine is seeking a post-doctoral trainee. The project involves studying conversion of highly mobile, phage-related staphylococcal pathogenicity islands into antibacterial agents. Work involves gene cloning, preparation and purification of phage-like particles, followed by testing for function in vitro and for treatment of experimental infections in mice. The project is described in the following article.

Looking for motivated postdoc who wants to explore virus diversity (in insects). This is part of an EU project, ViroplantH2020, and is a 2-year position. Experience in viral metagenomics and bionformatics required. Position available now in Montpellier, France. Contact @MOgliastro for details.

The Center for Phage Technology is looking for a Programmer I, which will, under direction, perform specialized software development and support functions such as troubleshooting, debugging, problem-solving, analysis, and research in a viral bioinformatics field.

The successful applicant will conduct research related to bacterial genomics, pathogenesis and molecular biology. The project entails dissecting the contribution of a novel bacteriophage in modulating cold-shock adaptation and animal model colonization using molecular cloning and gene knock-out/complementation techniques in Vibrio parahaemolyticus, a marine pathogen of human and ecological relevance.

Dr. Jennifer Brum is seeking a highly-motivated postdoctoral researcher to investigate viral ecology and viral effects on biogeochemical cycling in seven globally-distributed marine oxygen minimum zones (OMZs).

The Department of Plant Pathology and Environmental Microbiology is seeking a Research Technologist to perform a primary role in developing biological control cocktails that could be used to suppress bacterial blotch of mushroom in organic production systems. Specific projects will include enriching, isolating, and characterizing bacteriophage that specifically target blotch inciting pathogens, as well as screening mushroom colonizing non-pathogenic bacteria for the ability to antagonize mushroom pathogens.

Dr. Hany Anany is looking for a PhD student to join his growing research group starting from May 2019. The candidate will be working on investigating phage (free and immobilized) intervention during poultry carcass processing and packaging to control Campylobacter and Salmonella contamination. The project will include phage genome analysis, studying phage host interaction (transcriptome analysis) and metagenomics analysis of various environmental samples.

The candidate should meet the University of Guelph PhD admission requirements

(Important note: for non-Canadian students, meeting the English test requirement and having at least 80% in your MSc average are mandatory for this position)

Interested candidates should contact Dr. Anany directly (hany.anany@canada.ca) and send her/his CV ASAP.

The Center for Innovative Phage Applications and Therapeutics (IPATH) at the University of California, San Diego is seeking a postdoctoral fellow to investigate the effects of phages in altering the human microbiome and in combating pathogens.

The Institute of Virology is seeking a highly motivated postdoctoral researcher for the newly funded ERC project, with a particular emphasis on bacteriophage communities. The successful applicant will be involved in the development and the use of new methods and tools for illustrating bacteriophages infecting antibiotic resistance bacteria, including handling, analyzing and interpreting metagenomic and meta-transcriptomic (RNA-seq), proteomic data, as well as further development and/or application of multivariate analysis methods for comparative omics.

The Department of Biological Sciences in the School of Natural Sciences and Mathematics at The University of Texas at Dallas invites applications for an open rank faculty position in Biological Sciences.

Our preference is for applications at the Assistant Professor level, but we will also consider applicants at the Associate or Full Professor level.

Phage researchers (especially postdocs) encouraged to apply!

Desired start date: Aug. 1, 2019.
Open until filled.