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Before now, only eight phages and two archaeal viruses had been isolated from deep sea vents. Sarah Thiroux (Université de Bretagne Occidentale, France) and colleagues published a new paper describing another: the first head‐tailed virus in

Ever wondered about the biological function of genes that overlap with other genes? Bradley Wright (Macquarie University, Australia) and colleagues engineered the gene overlaps out of the φX174 phage genome and found that gene overlap was c

Charles Bernard (CNRS, France) and colleagues published a new paper in the ISME Journal describing their identification of a new communication system that may regulate host defense mechanisms (similar to the arbitrium system) in Bacillus ph

Saima Aslam (University of California, San Diego) and colleagues published a new paper in Open Forum Infectious Diseases showing the lessons the IPATH team has learned from their first 10 cases of IV phage therapy.

Sean Benler (NCBI) and colleagues published a new preprint on their identification of thousands of previously unknown phages in whole-community human gut metagenomes.

Laith Harb (Texas A&M University) and colleagues published a new paper in PNAS showing that host cell penetration by the F-pilus-specific ssRNA phage MS2 triggers detachment of the F-pilus.

Luís Melo (University of Minho, Portugal) and colleagues published a detailed analysis of how the Staphylococcus epidermidis biofilm matrix protects against phage predation.

Xing Wan (KU Leuven and University of Helsinki) and colleagues published a new review in Current Opinion in Biotechnology on phage-based target discovery and its exploitation towards novel antibacterial molecules.

Viperins are known to function in the eukaryotic antiviral response, and now they've been found in prokaryotes. Aude Bernheim (Weizmann Institute of Science) and colleagues published a new paper in Nature on prokaryotic viperins, which prot

The use and selection of excipients are critical to stabilize phages in solid formulations. Yajie Zhang (University of Texas at Austin) and colleagues have reviewed the current classes of phage excipients, outstanding challenges with phage

Niels Vander Elst (Ghent University) and colleagues published a new paper in Antibiotics on the characterization of two phage lysins, PlySs2 and PlySs9, which have in vitro lytic activity against bovine mastitis pathogen Streptococcus uberi

Lorenz Leitner (Balgrist University Hospital, Switzerland) and colleagues published a new paper in The Lancet Infectious Diseases on the results of a randomised, placebo-controlled, double-blind clinical trial to investigate intravesical ph

Tao Zuo (The Chinese University of Hong Kong) and collegues published a new paper in Cell Host & Microbe on the fecal DNA virome of 930 healthy adults from two regions in China spanning six ethnicities, including urban and rural residents.

Jānis Rūmnieks (Latvian Biomedical Research and Study Center, Latvia) and colleagues published a new paper in Science Advances showing the 3D structure of 22 uncultured ssRNA phages.

Diana Grubb (Colorado State University) and colleagues tested a phage prebiotic produced by Deerland Enzymes (Kennesaw, Georgia) in a placebo-controlled human clinical study, and found that administration of a phage cocktail alongside a bac

Kathy Lam (UCSF) and colleagues published a new preprint showing that M13 phage (engineered to express CRISPR-Cas9) can deplete specific strains of E. coli colonizing the mouse gut. They also used this system to create genetic deletions in

Andrew Favor (University of California, Berkeley and Nextbiotics, a California phage biotech company) and colleagues published a new paper in Scientific Reports on the new directed evolution-based phage engineering platform they've develope

Linyi Gao (Howard Hughes Medical Institute, Cambridge, MA) and colleagues published a new paper in Science describing their discovery of 29 new phage-protective gene cassettes, many of which incorporate enzymatic activities not previously i

Patrick de Jonge (Utrecht University, Netherlands) and colleagues published a new paper in iScience on AdsorpSeq, a new method for rapidly linking phages with hosts, which is based on sequencing phages physicially bound to host cell envelop

Cyclic-oligonucleotide-based anti-phage signalling systems (CBASS) share ancestry with an innate immune pathway in animals. Adi Millman (Weizmann Institute of Science, Israel) and colleagues published a new paper in Nature Microbiology on C