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Toronto clinician Dr. Greg German: reports the first research use of a phage cocktail to treat an infection in Canada!

This article by Mart Krupovic and colleagues discusses the origin of the eukaryotic cell and the last eukaryotic common ancestor (LECA). They reconstructed the LECA virus repertoire and found that the origin of the LECA virome can be traced

Y. Emre Gencay and colleagues have developed engineered phages with CRISPR-Cas machinery to reduce E. coli in mice. The phages, called SNIPR001, were well tolerated in mouse models and minipigs, and out-competed their ancestral wild-type ph

Matthew C Johnson and colleagues have shown that Pseudomonas aeruginosa exhibits the greatest diversity of anti-phage systems among 30 species. They identified two core defense hotspot loci (cDHS1 and cDHS2) where many anti-phage immune sys

Nature Biotechnology paper on SNIPR001: from a library of 162 wild-type phages, eight with broad E. coli coverage were selected and engineered with tail fibers and CRISPR–Cas machinery to target E. coli. A combination of the four most compl

This month, we talked about analyzing qPCR results, Phage Australia's official response to the Phage UK inquiry, and got hands on with building a project with ChatGPT! We put out some good work in April! This month we’ve been neck deep in d

The Israeli Phage Therapy Center (IPTC) has received 159 requests for phage therapy, with 38% of them being for multi-drug resistant bacteria. Respiratory and bone infections were the most prevalent indications. 20 phage therapy courses wer

In this preprint, Xin Tan and colleagues show that repeated doses of phage lead to faster phage clearance in rats and monkeys. The study found that while plasma phage titer gradually decreased over time following a single dose, repeated dos

Acne treatments often require extended periods and can be expensive, leading to the exploration of phages as an alternative. This study by Daniela Torres Di Bello and colleagues found that Pa.7 phage encapsulated in liposomes is not cytotox

Jody McKerral and colleagues analyzed >2.5 million prophages from >500,000 bacterial genome assemblies, revealing that 94% are lysogens containing at least one identifiable prophage. The findings provide a new framework for identifying phag

In this review, Juan Carlos García-Cruz and colleagues discuss multiple potential applications for phages beyond classical phage therapy, including cattle raising, agriculture, pest control, microbiome modulation, and disinfection.

University of Leicester is seeking a PhD student to test the host range and properties of existing mycobacterial phages and isolate new phages against M. tuberculosis and non-tuberculous mycobacteria (NTMs, such as Mycobacterium abscessus)

Dr. Andrea Fossati recently joined as an assistant professor in Karolinska Institute where he will explore the Mycobacterium immune system to understand molecular determinants for successful phage infection. Interested candidates may contac

The School of Plant Sciences in the University of Arizona is seeking a research technician with experience in single-stranded DNA virus assembly and packaging. The responsibilities include developing protocols, performing experiments, and l

The UK Phage Innovation Showcase will take place May 16th, 2023 from 9:30am-4pm in Leicester and online. The event is organized by Innovate UK KTN's Phage Innovation Network and the University of Leicester's recently launched Centre for Pha

The European Medicines Agency (EMA) is organizing a Focus Group meeting on 11 May 2023 to discuss the draft guideline on the quality, safety, and efficacy requirements for bacteriophage therapy in veterinary medicines. The aim is to establi

In this podcast, Dr. Jeremy Barr from Monash University and Phage Australia talks about his research on using phages to restore antimicrobial sensitivity in Acinetobacter baumannii.

University of Warwick and Cytiva authors show that poly(acrylic acid) prevents phage-induced killing of bacterial hosts and phage replication without affecting induction of recombinant protein expression, and was more active than poly(metha

Research Internship at Balgrist Univers in Zurich, Switzerland This full-time remunerated internship entails generating large scale datasets for phage activity against large collections of pathogenic bacteria, validating assays to best pred

Technician at Balgrist University Hospital in Zurich, Switzerland We are looking to hire a laboratory technician with a background in microbiology; experience with clinical samples or bacteriophages is an advantage but not required. The Gro