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Ep 18: Discussion of Phage Therapy for CF Patients - Rebekah Dedrick

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  1. UpdatesJun 14, 2024

    Deepto Mozumdar (University of California, San Francisco) and colleagues have characterized a new lipid-based jumbo phage com

    Deepto Mozumdar (University of California, San Francisco) and colleagues have characterized a new lipid-based jumbo phage compartment — a hub for early phage infection. The study explores how phage ΦKZ assembles a vesicle to protect its gen

    UpdatesJumbo phagePhage organellesResearch paper
  2. UpdatesJun 14, 2024

    Khalimat Murtazalieva (European Bioinformatics Institute) and colleagues have discovered 145 phage anti-defence systems (ADSs

    Khalimat Murtazalieva (European Bioinformatics Institute) and colleagues have discovered 145 phage anti-defence systems (ADSs) that counteract 27 of the 152 known bacterial defence families. They discuss high-throughput approaches which are

    UpdatesAnti-defense systemsComputational biologyResearch paper
  3. UpdatesJun 14, 2024

    Beatriz Beamud (Institut Pasteur) and colleagues have discovered that many bacterial defense systems against phages are encod

    Beatriz Beamud (Institut Pasteur) and colleagues have discovered that many bacterial defense systems against phages are encoded by mobile genetic elements, challenging traditional views of bacterial immunity.

    UpdatesMobile genetic elementsBacterial immunityResearch paper
  4. UpdatesJun 14, 2024

    In a new preprint, Ritam Das and Janina Rahlff (Friedrich Schiller University Jena, Germany) describe a positive correlation

    In a new preprint, Ritam Das and Janina Rahlff (Friedrich Schiller University Jena, Germany) describe a positive correlation between the number of structural genes and above-average guanine-cytosine (GC) content in phage genomes.

    UpdatesPreprintBioinformaticsGenome annotation
  5. Capsid & TailJun 7, 2024

    Insights from the 6th Bacteriophage Therapy Summit 2024

    This week we're featuring Michael Shamash's reflections on a couple of noteworthy topics covered at this year's Hanson Wade phage summit. Michael is a McGill University PhD student by day / awesome Phage Directory volunteer by night — thank

    Phage in AgricultureStandardsPhage Therapy ApplicationsRegulatory and Ethical Considerations
  6. JobsJun 7, 2024

    Franklin Nobrega (University of Southampton, UK) is hiring a PhD student to work on phage therapy for TB.

    Franklin Nobrega (University of Southampton, UK) is hiring a PhD student to work on phage therapy for TB.

    JobsPhD projectPhage therapyTB
  7. JobsJun 7, 2024

    McGill University (Montreal, Canada) is hiring a teaching assistant to assist with the Fall 2024 SEA-PHAGES: Phage Discovery

    McGill University (Montreal, Canada) is hiring a teaching assistant to assist with the Fall 2024 SEA-PHAGES: Phage Discovery course.

    JobsTeaching assistantSEA-PHAGES
  8. UpdatesJun 7, 2024

    Check out this episode of the Phage Therapy Today podcast, which features Dr. Mercedes Gonzalez from INCATE (an AMR startup f

    Check out this episode of the Phage Therapy Today podcast, which features Dr. Mercedes Gonzalez from INCATE (an AMR startup funder/accelerator) and Dr. Gregorio Iraola at Kinzbio, an INCATE recipient and founder of a new phage startup in Ur

    UpdatesCommunityPodcastFunding opportunitiesPhage therapyStartups
  9. UpdatesJun 7, 2024

    One hundred personalized phage treatments, combined! Not only did Jean-Paul Pirnay and colleagues at the Queen Astrid Militar

    One hundred personalized phage treatments, combined! Not only did Jean-Paul Pirnay and colleagues at the Queen Astrid Military Hospital in Belgium provide phages for 100 cases, they also published a full analysis of the outcomes! This led N

    UpdatesResearch paperPhage therapyCase series
  10. UpdatesJun 7, 2024

    Katie Wiebe (Cytophage Technologies, Inc) and colleagues have outlined a scalable and efficient production strategy for the E

    Katie Wiebe (Cytophage Technologies, Inc) and colleagues have outlined a scalable and efficient production strategy for the ETEC phage ‘Phage75’, which accounts for infection load, MOI, temperature, media, harvest time, and host bacteria (t

    UpdatesResearch paperPhage therapyPhage production
  11. UpdatesJun 7, 2024

    Qingquan (Kevin) Chen (Stanford University) and colleagues have demonstrated that filamentous Pf phages of P. aeruginosa hind

    Qingquan (Kevin) Chen (Stanford University) and colleagues have demonstrated that filamentous Pf phages of P. aeruginosa hinder antibiotic diffusion through CF sputum via electrostatic binding.

    UpdatesResearch paperPhage-antibiotic interactionsSputumCystic fibrosis
  12. UpdatesJun 7, 2024

    In a recent perspective piece, Christine Szymanski (University of Georgia) highlights the limitless resources for exploitatio

    In a recent perspective piece, Christine Szymanski (University of Georgia) highlights the limitless resources for exploitation that phages provide. She discusses their use in various fields such as phage therapy, gene transduction, and glyc

    UpdatesPerspectivePhage biotechnology
  13. UpdatesJun 7, 2024

    The Centre for Phage Research at the University of Leicester, UK is celebrating its one-year anniversary! Martha Clokie and A

    The Centre for Phage Research at the University of Leicester, UK is celebrating its one-year anniversary! Martha Clokie and Andrew Millard reflect on the first year.

    UpdatesPhage therapy centerReflection
  14. UpdatesJun 4, 2024

    Outcomes of 100 consecutive personalized phage therapy cases from a Belgian consortium (Nature Microbiology)

    A retrospective observational analysis of the first 100 consecutive cases of personalized phage therapy facilitated by a Belgian consortium in 35 hospitals across 12 countries (2008-2022) reports clinical improvement in 77.2% and eradicatio

    UpdatesPapersPhage Therapy
  15. Capsid & TailMay 31, 2024

    C&T Round Up for May 2024!

    Round up time! This month we covered why phage researchers are flocking to Australia in July (and California in June!), discussed our 'phage picks' for this month, and shared a very special story from one of the researchers that make up the

    Phage Community and CollaborationTechBioPhage Therapy Access and Implementation
  16. JobsMay 31, 2024

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring 1) a postdoc in phages and AMR to develop strategies to visualiz

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring 1) a postdoc in phages and AMR to develop strategies to visualize transduction dynamics; 2) a PhD student to characterize a unique staphylococcal phage-host library to assess and

    Jobs
  17. JobsMay 31, 2024

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring 1) a postdoc in phages and AMR to develop strategies to visualiz

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring 1) a postdoc in phages and AMR to develop strategies to visualize transduction dynamics; 2) a PhD student to characterize a unique staphylococcal phage-host library to assess and

    Jobs
  18. JobsMay 31, 2024

    University of Greifswald, Germany is hiring a research assistant to work on the ‘UtiliPhage’ project, establishing protocols

    University of Greifswald, Germany is hiring a research assistant to work on the ‘UtiliPhage’ project, establishing protocols for phage isolation, purify phages, determine immunogenicity and more.

    JobsResearch AssistantPhage isolation
  19. JobsMay 31, 2024

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring: - a postdoc in phages and AMR to develop strategies to visualiz

    Elena Gómez-Sanz (University of Bern, Switzerland) is hiring: - a postdoc in phages and AMR to develop strategies to visualize transduction dynamics - a PhD student to characterize a unique staphylococcal phage-host library to assess and me

    JobsPostdocTransductionAMRPhD Project
  20. JobsMay 31, 2024

    The Luque Lab at the University of Miami is hiring a postdoc to contribute to an innovative project combining structural viro

    The Luque Lab at the University of Miami is hiring a postdoc to contribute to an innovative project combining structural virology, multi-scale modeling, and environmental virology.

    JobsPostdocStructural Biology
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