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This paper by Samuel Barnett and Daniel Buckley explores the role of soil viruses in the carbon cycle. They added 13C-labelled carbon sources to soil and used metagenomic-SIP to detect 13C assimilation by viruses and their putative hosts. T

A new ISME Journal article by Xiang Tang and colleagues shows lysogenic phages with arsM-bearing markers help bacterial communities adapt to trivalent arsenic toxicity. The phage-host interaction enabled the quick spread of arsM among soil

Pulmonary infections caused by Mycobacterium abscessus have been increasing. This study by Mylene Gorzynski and colleagues deepens our understanding of phage–mycobacteria interaction mechanisms and identifies therapeutic phages that can low

Nature Communications paper using cryo-electron microscopy of short Ff-derived nanorods to determine a structure of a filamentous virus (f1, fd or M13 phages) including the tips. Combined with mutagenesis, it identifies phage domains import

The Phage Therapy Today podcast interviewed Johan Wikstroem, the CEO of tolka.ai, about his story in transitioning from tech to biotech and founding a phage therapy company with the goal of treating his own M. abscessus infection and helpin

Kids Research (part of Sydney Children's Hospitals Network) is hosting a webinar on May 19, 2023 at 2:00 PM AEST on phage therapy entitled "Phage Therapy in Australia: STAMPing out problematic infections". The webinar will be presented by P

From Sabrina Green via Twitter: Check out this documentary on #phage therapy in Belgium and Portugal. It is in Portuguese but interviews mostly in English.

The 2023 Symposium on New Concepts in Prokaryotic Virus-host Interactions (October 2-4, 2023) will bring together researchers studying new concepts and mechanisms in phage biology, with topics including viral cell biology, anti-viral defens

Our volunteer Atif Khan was selected for the FEMS #OnThisDay volunteer team. The #OnThisDayteam aims to assemble a collection of historically important microbiology events for every single day of the year. These events could be interesting

Evelien Adriaenssens wrote a piece for The Conversation on how thousands of phages (most of them unknown!) have been found in baby poo! The original study was done by a collaborative team from Denmark, Canada and France. And they even made

Toronto clinician Dr. Greg German: reports the first research use of a phage cocktail to treat an infection in Canada!

This article by Mart Krupovic and colleagues discusses the origin of the eukaryotic cell and the last eukaryotic common ancestor (LECA). They reconstructed the LECA virus repertoire and found that the origin of the LECA virome can be traced

Y. Emre Gencay and colleagues have developed engineered phages with CRISPR-Cas machinery to reduce E. coli in mice. The phages, called SNIPR001, were well tolerated in mouse models and minipigs, and out-competed their ancestral wild-type ph

Matthew C Johnson and colleagues have shown that Pseudomonas aeruginosa exhibits the greatest diversity of anti-phage systems among 30 species. They identified two core defense hotspot loci (cDHS1 and cDHS2) where many anti-phage immune sys

Nature Biotechnology paper on SNIPR001: from a library of 162 wild-type phages, eight with broad E. coli coverage were selected and engineered with tail fibers and CRISPR–Cas machinery to target E. coli. A combination of the four most compl

The Israeli Phage Therapy Center (IPTC) has received 159 requests for phage therapy, with 38% of them being for multi-drug resistant bacteria. Respiratory and bone infections were the most prevalent indications. 20 phage therapy courses wer

In this preprint, Xin Tan and colleagues show that repeated doses of phage lead to faster phage clearance in rats and monkeys. The study found that while plasma phage titer gradually decreased over time following a single dose, repeated dos

Acne treatments often require extended periods and can be expensive, leading to the exploration of phages as an alternative. This study by Daniela Torres Di Bello and colleagues found that Pa.7 phage encapsulated in liposomes is not cytotox

Jody McKerral and colleagues analyzed >2.5 million prophages from >500,000 bacterial genome assemblies, revealing that 94% are lysogens containing at least one identifiable prophage. The findings provide a new framework for identifying phag

In this review, Juan Carlos García-Cruz and colleagues discuss multiple potential applications for phages beyond classical phage therapy, including cattle raising, agriculture, pest control, microbiome modulation, and disinfection.