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The Mayo Clinic has invested $1.75 million in Adaptive Phage Therapeutics, which will allow APT to initiate a clinical trial to address periprosthetic joint infections (an estimated commercial market of $900 million per year). The trial is

Rijul Kochhar (MIT) published a new article on the pre-d’Hérelle history of phages, and the many meanings of phages today in the space of this ‘pre-discovery’. It’s a story of science, religion and late 19th century colonial healthcare with

Jimmy Trinh (Texas A&M University) and colleagues published a new paper in Nature Communications looking at lambda phage infecting single host cells using live-cell and in-situ fluorescence imaging. They found that different viral DNAs esta

Holger Loessner (Paul-Ehrlich-Institut, Germany) and colleagues published a new paper in Antibiotics on the use of kinetic fingerprinting to explore the dynamics of specific phage-host pairs, with the goal of designing effective phage thera

Karim Abdelkader (Ghent University) and colleagues published a new paper in Applied and Environmental Microbiology showing that an Acinetobacter baumannii phage lysin has a turgor pressure-dependent intrinsic antibacterial activity and can

Vito Adrian Cantu (San Diego State University) and colleagues published a new preprint on Phage Artificial Neural Networks (PhANNs), a fast and accurate machine learning tool and web server that can classify phage proteins into ten major cl

Huijun Geng (Dalian University of Technology, China) and colleagues published a paper looking into phage therapy as a treatment for Staphylococcus aureus-induced mastitis using a mouse model. Mice with induced mastitis showed improved masti

Martin Inyimili I have been working on phages from 2018. I now have several phages which I need to extract their DNA and sequence on the nanopore sequencer. Can someone help me on how to do this especially sequencing several samples at once

Phage Directory Our next PHAVES event will take place Aug. 4 at 11:00 AM EST / 8:30 PM IST. We'll be interviewing Pranav Johri and Apurva Virmani Johri, founders of Vitalis Phage Therapy, about their impressive progress improving access to

Phage Directory We'd like to give a shout-out to our new volunteers, M. R. Madhav (phage protocols curator for our future phage protocol compendium), Curtis Hoffmann (Twitter and LinkedIn), and Lizzie Richardson (Capsid & Tail feature editi

Innovative Solutions Canada Innovative Solutions Canada is looking to fund small businesses developing phytosanitary treatment options to control plant pests. Maybe a job for phages?

Elizabeth Svoboda wrote a Nature Outlook article diving into the current state of phage therapy options for cystic fibrosis patients, and initiatives working to make this a reality. We're thrilled to see Phage Directory highlighted in this

The aquaculture industry continues to move toward phage therapy; here's a recent review published in Antibiotics by Justyna Kowalska (Proteon Pharmaceuticals) colleagues. Read the highlights in this article on The Fish Site.

Christopher Duplessis and Biswajit Biswas (US Naval Medical Research Center) published a new systematic review in Antibiotics on topical phage therapy for chronically infected wounds. They also discuss their preparations for a phase II rand

Legesse Garedew Kifelew (Flinders University, Australia) and colleagues published a new paper in BMC Microbiology showing efficacy of a cGMP-produced phage cocktail in treating diabetic mouse wound infections caused by MRSA. They applied th

Here's a streamlined new method for producing phages (and removing endotoxin) for personalized phage therapy, published in Nature Protocols by Tiffany Luong (San Diego State University) and colleagues.

Some bacteria release colicins to kill competitors by carefully timing lysis for part of their population at a time. But group B colicins don't come with lysis genes, so how do cells safely release them? Stefanie Spriewald (LMU Munich, Germ

Multicopy plasmids contribute to antimicrobial resistance gene transfer, and although many don't contain mobility genes, they've been observed to contain phage fragments. Lorena Rodríguez-Rubio (Universitat de Barcelona, Spain) and colleagu

We don't know much about phages in groundwater reservoirs, even though bacteria in these environments are thought to influence biogeochemical cycles. Ole Hylling (Aarhus University, Denmark) and colleagues published a new paper in Scientifi

Only a handful of prophage genomes targeting the phytopathogen Erwinia are available. In a new paper published in Frontiers in Microbiology, Nikita Zrelovs (Latvian Biomedical Research and Study Centre) and colleagues delved into temperate