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Holger Loessner (Paul-Ehrlich-Institut, Germany) and colleagues published a new paper in Antibiotics on the use of kinetic fingerprinting to explore the dynamics of specific phage-host pairs, with the goal of designing effective phage therapies. For a Klebsiella pneumoniae phage-host pair, they saw that a reduction in bacterial concentration required a high multiplicity of infection, complete bacterial clearance was hard to accomplish, and binding affinity was one of the most crucial factors for bacterial reduction.

SourceCapsid & Tail #87