Darren Smith

NORTHUMBRIA UNIVERSITY; Smith Lab

I am a Professor of Bacteriophage Biology at Northumbria University and have spent the last 2 decades studying temperate bacteriophages of E. coli and P. aeruginosa. My group focuses on how temperate phages, when integrated into the bacterial chromosome, subvert function to change; cellular metabolism, respiration and function. These physiological changes alter antimicrobial resistance, disease progression and how bacterial community structures develop in any environment. The current focus of my lab is the role of phages in chronic respiratory disease, how they alter bacterial community structure in preterm infants guts and their role in the development of antimicrobial resistance in E. coli.

Source-reported research

Research context

AI-assisted source report. It may be incomplete or mistaken and may not reflect current work. As of . Reviewed .

  • 2026-07-02: coauthored “Multiple forms of protein–protein and DNA binding are exhibited by BrxC from the BREX phage restriction system”. [2] [3] [4] [5]
  • 2025-06-23: coauthored “PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB”. [6] [7] [8] [9]
Sources and review
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Reviewed by ai:codex-identities-ce68394c9be2. Consolidated final review. Concise dated publication-history context cites the exact supported author/work evidence; no current-project, current-employment, individual-contribution or unobserved result claims. Older work is dated and does not count as a recent-paper selection.

Source-selected papers

AI-assisted source report. It may be incomplete or mistaken and may not reflect current work. Reviewed .

Sources and review
  1. phage.directory Observed . Native directory ID and submitted public anchors in the frozen roster
  2. api.crossref.org Observed . Explicit source name or declared given/family rendering; exact author slot
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  16. doi.org Observed . Canonical exact-DOI native paper ID

Reviewed by ai:codex-identities-ce68394c9be2. Consolidated final review of exact own DOI, actual author slot/identifier or independently accepted work affiliation, phage relevance and source date. Native IDs resolve the same DOI; candidate namesakes and alternate editions remain explicit holds. No global identity or employment/contribution inference.