Clinical study
diSArm
Study Evaluating Safety, Tolerability, and Efficacy of Intravenous AP-SA02 in Subjects With S. Aureus Bacteremia
| Status | Completed |
|---|---|
| Type | Trial |
| Countries | Australia; United States |
| Conditions studied | Bacteremia; Staphylococcus Aureus; Staphylococcus Aureus Bacteremia; Bacteremia Staph; Bacteremia Due to Staphylococcus Aureus |
| Study years | 2022–2025 |
| Entry review | 2026-10-03 |
Participation
Check the study record or contact the study team for current recruitment and eligibility.
Study eligibility
Key Inclusion Criteria: * A hospitalized female or male ≥ 18 years old * Positive blood culture for Staphylococcus aureus (SA) * Source of SA infection controlled, or a plan for source control, if relevant * Not pregnant or breastfeeding and is not of reproductive potential or agrees to use contraception if or reproductive potential Key Exclusion Criteria: * Concomitant growth of organisms besides SA * Left-sided infectious endocarditis by modified Duke criteria * Known or suspected brain abscess or meningitis * Known allergy to phage products
Study description
Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Escalation Study of the Safety, Tolerability, and Efficacy of Intravenous AP SA02 as an Adjunct to Best Available Antibiotic Therapy Compared to Best Available Antibiotic Therapy Alone for the Treatment of Adults With Bacteremia Due to Staphylococcus aureus
Study registrations
| ClinicalTrials.gov | NCT05184764 |
|---|
Recorded study locations (28)
Locations listed in the study record; this does not confirm current recruitment or treatment outside the study. A site label may be older than the overall study status.
Banner University Medical Center
Tucson, Arizona, United States
Recorded site status: Not separately listed. Study location source ↗
University of California, San Diego (UCSD) - Medical Center
La Jolla, California, United States
Recorded site status: Not separately listed. Study location source ↗
University of Southern California Keck School of Medicine
Los Angeles, California, United States
Recorded site status: Not separately listed. Study location source ↗
University of California, Los Angeles (UCLA) - Medical Center
Los Angeles, California, United States
Recorded site status: Not separately listed. Study location source ↗
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
Torrance, California, United States
Recorded site status: Not separately listed. Study location source ↗
Rocky Mountain Regional VA Medical Center
Aurora, Colorado, United States
Recorded site status: Not separately listed. Study location source ↗
University of Florida (UF) - Division of Infectious Disease
Gainesville, Florida, United States
Recorded site status: Not separately listed. Study location source ↗
University of Florida - Jacksonville
Jacksonville, Florida, United States
Recorded site status: Not separately listed. Study location source ↗
University of South Florida
Tampa, Florida, United States
Recorded site status: Not separately listed. Study location source ↗
Emory University Hospital Midtown
Atlanta, Georgia, United States
Recorded site status: Not separately listed. Study location source ↗
Johns Hopkins University
Baltimore, Maryland, United States
Recorded site status: Not separately listed. Study location source ↗
Tufts Medical Center
Boston, Massachusetts, United States
Recorded site status: Not separately listed. Study location source ↗
University of Michigan
Ann Arbor, Michigan, United States
Recorded site status: Not separately listed. Study location source ↗
Henry Ford Health System
Detroit, Michigan, United States
Recorded site status: Not separately listed. Study location source ↗
The Jamaica Hospital Medical Center
Jamaica, New York, United States
Recorded site status: Not separately listed. Study location source ↗
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Recorded site status: Not separately listed. Study location source ↗
Montefiore Medical Center
The Bronx, New York, United States
Recorded site status: Not separately listed. Study location source ↗
University of North Carolina - Chapel Hill School of Medicine
Chapel Hill, North Carolina, United States
Recorded site status: Not separately listed. Study location source ↗
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Recorded site status: Not separately listed. Study location source ↗
Rhode Island Hospital
Providence, Rhode Island, United States
Recorded site status: Not separately listed. Study location source ↗
Regional One Healthcare
Memphis, Tennessee, United States
Recorded site status: Not separately listed. Study location source ↗
Methodist Hospital Research Institute - Houston
Houston, Texas, United States
Recorded site status: Not separately listed. Study location source ↗
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Recorded site status: Not separately listed. Study location source ↗
Royal Adelaide Hospital
Adelaide, Australia
Recorded site status: Not separately listed. Study location source ↗
Monash Health
Clayton, Australia
Recorded site status: Not separately listed. Study location source ↗
Royal Melbourne Hospital
Melbourne, Australia
Recorded site status: Not separately listed. Study location source ↗
The Alfred Hospital
Melbourne, Australia
Recorded site status: Not separately listed. Study location source ↗
Westmead Hospital
Westmead, Australia
Recorded site status: Not separately listed. Study location source ↗
Related programs(1)
Armata Pharmaceuticals
Research/development
Recorded program–study link. Website
Sources and updates
Entry reviewed . This is the date of our source review, not a confirmation of availability today.
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| Study ID | nct05184764 |
|---|