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🎙️ New Podovirus Podcast Episode Alert!

I had such a great time talking to Jesus Fernandez-Rodriguez, PhD, VP of Technology at Eligo Bioscience, about how they're editing live microbes in the mouse gut with engineered phages!

🧬 Highlights & questions:

• 93% editing efficiency in gut E. coli with a single dose of a phage-derived base editor! (And it lasts for at least 6 weeks...!)
• Where are we at with microbiome therapeutics?
• How do you make phages deliver genes to live microbes?
• Is this tool just as cool as a perturbing device (to ASK questions about what happens when you turn off a bacterial gene in the gut) as it is a therapeutic?

Check out the full episode here: 🎧Spotify 📺 Youtube

📄 Here's the team's new Nature paper

🤔One thing I really wanted to know, but must remain a secret for a bit longer — what should we be targeting first with something like this?

Would love to hear your thoughts!