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Eleanor Townsend and Eleanor Jameson (University of Warwick) are editing a special issue titled “Phage-Host Interaction in the Gut Microbiome and Their Impacts on Human Health and Disease” in MDPI’s International Journal of Environmental Research and Public Health. The special issue focuses on the understudied regulatory interactions of phages with gut microbiota and the impact of human gut phageome on human health and diseases with the ultimate aim of bringing up phages for human health benefits.