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By analyzing metagenomic samples from IBD patients, Shaqed Carasso (Technion-Israel Institute of Technology) and colleagues identified invertible regions that correlate with disease, including Bacteroides fragilis polysaccharide-A, which is mostly 'OFF'-switched during inflammation, but switches ‘ON’ when inflammation is resolved. Intriguingly, they found that phages seem to induce the 'OFF' switch...