Bacteriophage Therapy in Patients With Prosthetic Joint Infections

General Inclusion Criteria: * Males or females ≥18 years of age. * Female patients of childbearing potential who agree to use contraception. * Candidate for a two-stage exchange arthroplasty. * Chronic prosthetic joint infection General Exclusion Criteria: * Prior history of prosthetic joint infections (PJI) of same joint treated surgically other than one prior Debridement Antibiotics and Implant Retention procedure * Soft tissue defect requiring reconstruction * Hardware misalignment or loosening * Active osteomyelitis * Septic shock or hemodynamic instability * Stage 4 or greater chronic kidney disease * Liver disease * Decompensated cirrhosis * Alcohol abuse or alcohol induced liver disease or non-alcoholic steatohepatitis * Decompensated heart failure * Any other clinically significant disease, per judgement of the investigator * Neutropenia (neutrophil count \< 1000 cells/cubic mm), thrombocytopenia (platelets \< 50,000/cubic mm) or aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) \> 3 time the upper limit of normal * HIV, hepatitis C, hepatitis B infection * Positive drug screen * Receipt of chemotherapy, immunosuppressants or immune modulators * Anti-viral medication * Any known phage allergy * Breast feeding or pregnancy