Clinical study
PHAGE-2024-01
Bacteriophage Therapy for Methicillin-Sensitive Staphylococcus Aureus Prosthetic Joint Infection
| Status | Active, not recruiting |
|---|---|
| Type | Individual-case protocol |
| Countries | Canada |
| Conditions studied | Prosthetic Joint Infections of Hip; Staphylococcus Aureus Infection |
| Study years | 2024–2025 (estimated) |
| Entry review | 2026-10-03 |
Participation
Check the study record or contact the study team for current recruitment and eligibility.
Study eligibility
Inclusion Criteria: * Diagnosis of active chronic prosthetic joint infection * Causative bacteria is susceptible to bacteriophage therapy in vitro * History of multiple failed antibiotic and surgical interventions Exclusion Criteria: * Stage 5 chronic kidney disease * Cirrhosis * A known allergy to phage products * Fever * Involvement in another clinical trial * Pregnancy
Study description
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage cocktail to treat and prevent the recurrence of a methicillin-susceptible Staphylococcus aureus prosthetic joint infection of the hip. The patient has exhausted all conventional therapies, both surgical and medical, at considerable detriment to his quality of life. The treatment involves a one time, intra-operative injection of bacteriophages into the joint and 14 days of intravenous phage therapy. The goal is to eliminate the infection and prevent further complications, providing a potential new treatment avenue for patients with difficult-to-treat infections.
Study registrations
| ClinicalTrials.gov | NCT06456424 |
|---|
Recorded study locations (1)
Locations listed in the study record; this does not confirm current recruitment or treatment outside the study. A site label may be older than the overall study status.
South Health Campus
Calgary, Alberta, Canada
Recorded site status: Not separately listed. Study location source ↗
Related programs(1)
University of Calgary / Alberta Health Services phage research
Intake unconfirmed
Recorded program–study link. Website
Notes from the source review
- Single-patient protocol (target/actual n=1); not a broad recruiting program. Planned completion date has passed while registry status remains nonterminal; recheck with site.
Sources and updates
Entry reviewed . This is the date of our source review, not a confirmation of availability today.
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| Study ID | nct06456424 |
|---|