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Giada Finocchio (University of Zurich) and colleagues have discovered the target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA, shedding light on the structural architecture and catalytic activation of the syste

Tomoyoshi Kaneko (Waseda University, Tokyo) and colleagues isolated 28 phages infecting E. coli and evaluated factors like lysis activity, adsorption rate and burst size. They found that variation in lysis onset time and duration was higher

Stanford researchers show that the temperate filamentous phage Pf4 of Pseudomonas aeruginosa is decorated with outer membrane vesicles whose short RNAs trigger TLR3-dependent type I interferon production and suppress antibacterial cytokines

Monash University researchers applied highly purified phage T4 to mammalian cells in vitro and found it was rapidly internalized into macropinosomes without activating the TLR9 or cGAS-STING DNA-sensing pathways. T4 instead activated AKT-de

Researchers at Skoltech report the full genome sequence and virion protein content of Escherichia coli phage BF23, a close relative of T5 that was isolated in the mid-twentieth century. BF23 resists Types I/II/III restriction-modification s

Singapore University of Technology and Design researchers combined M13-conjugated polyethylene glycol with tungsten disulfide nanosheets to build a Phage-based Digital Biomolecular Sensor (P-DBS) for MCF-7 cancer cells. The sensor reached a

The Center for Vaccine Development and Global Health at University of Maryland is recruiting healthy volunteers for an investigational Shigella challenge study to evaluate the effectiveness of phages in treating Shigella infections. Volunte

Phage Futures: Global Digital Summit is happening October 25, 2023, and will focus on accelerating the translation of phages into viable therapeutics and commercial solutions. Book your free pass here!

Professor Martha Clokie and Dr Anisha Thanki have been awarded £800,000 from the UK BBSRC to advance the production of safe and effective phages for combating disease in the veterinary field, with the aim of bringing them to market in accor

Intralytix, Inc. has been issued a patent by the European Patent Office for several Shigella phages and their applications and formulations.

The European Medicines Agency have published a new guideline on the quality, safety, and efficacy of phages as veterinary medicines.

Lydia Chambers and colleagues discovered that bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems, revealing strong parallels between bacterial and eukaryotic ubiquitination pathways.

Rani Brooks, Lisa Morici, and Nicholas Sandoval found that cell free phage synthesis from engineered strains improves yield.

This month on the PhageCast podcast, a new episode format has been released, with a focus on short stories from PhD students or early stage researchers. It has been opened up with Veronique Ongenae and her recently released paper: "Reversib

UCSD will soon open as a clinical trial site for Adaptive Phage Therapeutics' ACTIVE.2 trial, studying the safety and efficacy of APT's Phage Bank versus placebo in patients with prosthetic joint infections.

Heather Hendrickson and Peter Fineran have had a major new phage project funded: ~9 million to set up a phage pipeline to protect primary industries in New Zealand, such as kiwifruit and apiculture sectors. Their programme aims to create a

Kaat Schroven (KU Leuven) and colleagues discovered that the phage protein PIT2 directly interacts with the LasR T2SS effector, interfering with P. aeruginosa quorum sensing and attenuating virulence, inspiring a new potential phage-encoded

Julián Bulssico (Aix-Marseille Université) and colleagues have discovered that cell filamentation plays a key role in successful phage predation, leading to phage-antibiotic synergy.

Leo Kan and Jeremy Barr (Monash University, Australia) have written a new review entitled ‘A Mammalian Cell’s Guide on How to Process a Bacteriophage’.

I am a phage enthusiast and my abstract on phage therapy was accepted by the African Genetic Biocontrol Consortium for oral. However, I had to cater for registration, accommodation and travel fees. Unfortunately, I had to decline my partici