The current research in the Nelson lab is centered on proteins that are part of the bacteriophage lytic system. These proteins, known as lysins or endolysins, have the ability to rapidly bind to and degrade the cell wall of a host species. As such, they represent an alternative approach to conventional antibiotics. We work on all aspects of endolysins development: discovery, host-range analysis, biochemical and biophysical characterization, microbiological parameters, and efficacy studies. Most recently, we have focused on structure/function studies for several of the more active endolysins. Based on this collected knowledge, the group is now generating endolysins with more desirable attributes, such as higher activity, an expanded host range, or a more favorable thermostability profile. It is anticipated these bioengineering approaches will result in development of the next generation endolysins with enhanced properties.
