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Long-read genome sequencing suffers from high DNA requirements and sequencing errors, so Olivier Zablocki (Ohio State University) and colleagues developed VirION2, an integrated short- and long-read metagenomic wet-lab and informatics pipeline. Check out their new preprint here, where they show how VirION2 sample prep and workflow can help researchers better investigate the virosphere, even when analyzing low-biomass samples. Find VirION2 on Protocols.io