Postdoctoral Research Associate in BREX and Phage-resistance mechanisms
Dr. Tim Blower, Durham, UK
Applications are invited for a Postdoctoral Research Associate in BREX phage-resistance systems.
BREX methylates the host at specific recognition sequences, but the mechanism of BREX phage protection is not yet understood. This research programme contains three interconnected objectives: (1) Define the essential components and interactions within BREX loci using an E. coli model; (2) Define the biochemical activity and structure of BREX components and/or complexes; (3) Define how bacteriophages become BREX-resistant. These aims will be achieved using a range of techniques including microbiology, molecular biology, biochemistry, structural biology (X-ray crystallography, cryo-EM) and genomics. The project will be supported by two PhD studentships. The post is full time and fixed term for 36 months.
Tim Blower can be contacted for informal enquiries at timothy.blower@durham.ac.uk
| Original listing | Durham University, The Blower Lab |
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