Genome-based prediction of strain-level phage-host interactions across Escherichia, with a phage cocktail pipeline (Nature Microbiology)

Using a dataset of interactions between 403 Escherichia strains and 96 phages, researchers predicted strain-level phage-bacteria outcomes from genomic data alone (AUROC 86%) and found that adsorption factors explain most interactions while antiphage systems play a marginal role. They also built a pipeline that recommends tailored phage cocktails, demonstrated on 100 pathogenic E. coli isolates.