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Engineering phages is getting more popular; here's another breakthrough in phage synthetic biology! Matthew Dunne (ETH Zurich) and colleagues have developed several approaches for engineering phages targeting Gram-positive pathogens (using Listeria as a model), including structure-guided design of phages with chimeric receptor binding proteins (RBPs), as well as RBP mutagenesis approaches that do not require prior knowledge of RBP structure or its receptor epitope.