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Cédric Lood (KU Leuven) and colleagues published a new paper on jumbo phage-host interactions: they used an integrative omics approach (hybrid sequencing, RNAseq, and mass spectrometry) to look at Pseudomonas aeruginosa phage PA5oct and its host. They were able to annotate it accurately, look at gene expression patterns during infection, and place the phage among other phages using a gene-sharing network.