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Branko Rihtman (University of Warwick) and colleagues have published a new paper in Current Biology on their identification of an unusual nucleotide substitution from deoxythymidine to deoxyuridine in a novel family of phages belonging to Naomiviridae. Due to these substitutions, the phage DNA is resistant to digestion by common restriction enzymes such as EcoRV, XbaI and HindIII.