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As there is currently no gold standard for developing a phage cocktail, Melissa Haines (University of Leicester, UK) and colleagues set out to describe a novel approach to phage cocktail development by comparing different methods side by side. They found that for phages targeting ESBL-producing E. coli and Klebsiella UTI isolates, planktonic killing assays were as effective as efficiency of plating assays, while being much less time consuming.