Ami Bhatt on the microbiome, hospital superbugs and phage-derived recombinases for in vivo CAR-T engineering (Stanford Medicine podcast)

In an episode of Stanford Medicine's The Future of Medicine, hematologist and microbiome researcher Dr. Ami Bhatt discusses tracing about 40% of bloodstream infections in a Stanford bone marrow transplant population to microbes already living in patients' guts, and how "jumping genes" may help Enterococcus faecium emerge as a hospital superbug. She also describes using large serine recombinases from phages, whose job is to integrate phage genomes into bacterial genomes, to convert T cells into CAR-T cells inside the body, work spun out as Stylus Medicine.