IPATH has just received FDA approval to start its first clinical trial! This will be the first US trial involving intravenous (IV) phage treatment, and will be a collaboration with Ampliphi Biosciences.
Johnson & Johnson has invested $20 million (with another ~$800 million to follow if things go well) into Locus Biosciences, a biotech company equipping phages with CRISPR-Cas3 to obliterate bacterial DNA upon phage infection.
A phase II clinical trial for a phage lysin has been deemed successful! An anti-Staphylococcus aureus phage lysin, called exebacase, was just found to be both safe and effective at treating MRSA in patients. Exebacase is being developed by ContraFect using technology licensed from Rockefeller University.
The phage therapy biotech company Ampliphi Biosciences is merging with C3J Therapeutics, a synthetic phage/antimicrobial engineering company.
Due to the partial U.S. government shutdown, ASM is extending the deadline for ASM Microbe abstract submissions to January 25, 2019.
Thanks to support from Roche Molecular Diagnostics and Intralytix, ASM Division M will provide 4 travel awards to students presenting phage work at ASM Microbe 2019! To apply, use “phage” as a keyword in your submitted abstract. Before you do, go to http://myasm.asm.org to become a Division M (Bacteriophage) member, as preference for awards is given to students who are members (and whose mentors are too).
UT Dallas is hiring an open rank biology faculty member in Biological Sciences. Phage researchers (especially postdocs) encouraged to apply!. Desired start date: Aug. 1, 2019.
The University of Laval in Quebec, Canada has an opening for a postdoc in food virology. Apply by Feb. 15, 2019.
Have a question or request for the phage community? Post it here and reach > 300 phage enthusiasts spanning academia, industry, medicine, and beyond. Feel free to be creative about what you might ask! (e.g. collaborations, advice, seeking opportunities). Find the week’s new requests here in Capsid & Tail, or find a list of all active requests here.
Have a question or request for the phage community? Post it here and reach > 200 phage enthusiasts spanning academia, industry, medicine, and beyond. Feel free to be creative about what you might ask! (e.g. collaborations, advice, seeking opportunities)
I’m a postdoc at Harvard Medical School researching a novel phage-immunity system in Salmonella enterica sv. Typhimurium. I’m looking for characterised (and ideally genome sequenced/published) phages infecting S. Typhimurium to test against the system. So far I have the phages P22, BTP1, det7, 9NA and FelixO1, but I would really like some more diverse Salmonella phages, particularly those that adsorb to non-LPS receptors. Note: other collaborators in this project are located in the UK, so I am looking for people who could send phages to either the US or the UK. Email Sian at [email protected] if you can help!
I’m working on a deep learning-based analysis of phage genomes considering their lytic/lysogenic potential. I’m looking for complete phage genome sequences in FASTA format with lytic/lysogenic labels that have been confirmed by domain experts. Email Piotr at [email protected] or tweet @ptynecki if you can help!
I am Muhammad Akmal, working as a Lecturer at the Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan since July 2014, where I also received my Bachelors and Masters degrees in Fisheries and Aquaculture. I am now pursuing a second Masters in Fisheries Science at Pukyong National University, South Korea (ends Feb. 2019). Previously I worked on isolation and characterization of fish pathogenic Aeromonas hydrophila for the possible control of motile aeromonas septicemia in fish. Now I am searching for a PhD position in phage therapy-related aquaculture. I am open to any available opportunity where I can learn more about the phage therapy, especially in control of disease in aquaculture. Please email Rana at [email protected] if you know of any opportunities.
Hi phage community! Do you have any old micropipettes that you’re ready to get rid of? If so, Phages for Global Health regularly needs micropipette donations for our laboratory training workshops in Africa. We could use any sizes 10 - 1000 uL. Please email me if you have any donations or questions: [email protected].
My name is Gunaraj Dhungana, I’m a Ph.D scholar from the central Department of Biotechnology, Tribhuvan University, Nepal. We have sequenced the whole genome of four lytic phages against carbapenem-resistant and colistin resistant clinical isolates like Klebsiella pneumoniae, Acinetobacter baumannii, Salmonella spp and Pseudomonas aeruginosa by next-generation sequencing using Illumina platform. I am searching for help/advice/mentorship with the bioinformatic analysis of sequenced data. Please email me at [email protected].
We’d like to have answers for people when they visit our site, so we’re building a Phage Therapy FAQ page. To maximize the info we can provide, we’re going to link to other phage therapy FAQ pages whenever possible. We’d also like to draw upon the phage community (all of you) for help.
If you have a bacterial infection, and it will not respond to antibiotics, you could be eligible for phage therapy. In most countries, phage therapy remains an experimental treatment, and thus must be done according to experimental treatment guidelines (which vary according to the country you’re in).
Phage therapy must always be supervised by a licensed physician, and in most countries, the physician will have to work with the national regulatory body to apply for approval to treat your infection with phages. You will need to know the identity of the bacteria causing your infection, which generally requires that the bacteria causing your infection are cultured.
There are only a few established phage therapy centers in the world, and many patients travel thousands of miles to be treated at these centers. If a person does not wish to or cannot travel for treatment, phage therapy can sometimes be set up to occur at a patient’s local clinic or hospital.
DISCLAIMER: We cannot and do not give medical advice. The information we provide here is intended to help you understand the process a little bit more and to help direct you to professionals who can help you learn if phage therapy is right for you. All decisions to pursue or proceed with phage therapy must be done under the direct supervision of a licensed physician.
Thanks for reading!
For every issue of Capsid & Tail, we are committed to getting our facts straight, but we’re not experts in the information we’re bringing to you. If you feel that we’ve missed an important viewpoint, or if you have something to add, please reach out to us by emailing [email protected]. We’d love to hear from you, and we’d be happy to revisit topics we’ve covered (ideally with added information and viewpoints from community members like you!).
Lastly, please reach out if you’re interested in writing for us, or have suggestions for future issues!